Evidence map›Paper›PMID 37370825›Full record

ArticleCancers2023

Prediction of Prostate Cancer Biochemical and Clinical Recurrence Is Improved by IHC-Assisted Grading Using Appl1, Sortilin and Syndecan-1.

Jessica M Logan, Ashley M Hopkins, Carmela Martini, Alexandra Sorvina, Prerna Tewari, Sarita Prabhakaran, Chelsea Huzzell, Ian R D Johnson, Shane M Hickey, Ben S-Y Ung and 29 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors at 8 institutions in 3 countries.

Jessica M LoganClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia.ORCID 0000-0003-4046-6908
Ashley M HopkinsCollege of Medicine and Public Health, Flinders University, Flinders Drive, Bedford Park, Adelaide, SA 5042, Australia.ORCID 0000-0001-7652-4378
Carmela MartiniClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia.
Alexandra SorvinaClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia.ORCID 0000-0002-5918-3038
Prerna TewariDepartment of Histopathology, Trinity College Dublin, D02 PN40 Dublin, Ireland.
Sarita PrabhakaranDepartment of Anatomical Pathology, College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia.ORCID 0000-0003-3252-2519
Chelsea HuzzellClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia.ORCID 0000-0002-1524-3457
Ian R D JohnsonClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia.ORCID 0000-0001-7875-3510
Shane M HickeyClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia.ORCID 0000-0002-3063-531X
Ben S-Y UngClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia.ORCID 0000-0001-7667-3648
Joanna LazniewskaClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia.
Robert D BrooksClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia.ORCID 0000-0003-1535-8999
Courtney R MooreClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia.ORCID 0000-0003-3675-4026
Maria C CarusoClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia.ORCID 0000-0001-7971-0651
Litsa KarageorgosClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia.
Cara M MartinDepartment of Histopathology, Trinity College Dublin, D02 PN40 Dublin, Ireland.
Sharon O'TooleDepartment of Histopathology, Trinity College Dublin, D02 PN40 Dublin, Ireland.ORCID 0000-0002-9260-3225
Laura Bogue EdgertonDepartment of Histopathology, Trinity College Dublin, D02 PN40 Dublin, Ireland.
Mark P WardDepartment of Histopathology, Trinity College Dublin, D02 PN40 Dublin, Ireland.ORCID 0000-0002-9356-7246
Mark BatesDepartment of Histopathology, Trinity College Dublin, D02 PN40 Dublin, Ireland.ORCID 0000-0002-5916-5403
Stavros SelemidisSchool of Health and Biomedical Sciences, STEM College, RMIT University, Bundoora, Melbourne, VIC 3001, Australia.ORCID 0000-0002-3989-7615
Adrian EstermanClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia.
Sheena HeffernanDepartment of Pathology, The Coombe Women and Infants University Hospital, D08 XW7X Dublin, Ireland.
Helen KeeganDepartment of Histopathology, Trinity College Dublin, D02 PN40 Dublin, Ireland.
Sarah Ní MhaolcathaDepartment of Pathology, The Coombe Women and Infants University Hospital, D08 XW7X Dublin, Ireland.
Roisin O'ConnorDepartment of Pathology, The Coombe Women and Infants University Hospital, D08 XW7X Dublin, Ireland.
Victoria MaloneDepartment of Pathology, The Coombe Women and Infants University Hospital, D08 XW7X Dublin, Ireland.
Marguerite CarterDepartment of Pathology, The Coombe Women and Infants University Hospital, D08 XW7X Dublin, Ireland.
Katie RyanDepartment of Pathology, The Coombe Women and Infants University Hospital, D08 XW7X Dublin, Ireland.
Andres ClarkeDepartment of Pathology, The Coombe Women and Infants University Hospital, D08 XW7X Dublin, Ireland.
Nathan BradyDepartment of Pathology, The Coombe Women and Infants University Hospital, D08 XW7X Dublin, Ireland.
Sonja KlebeDepartment of Anatomical Pathology, College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia.ORCID 0000-0002-8976-4714
Hemamali SamaratungaAquesta Uropathology, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0001-5796-1791
Brett DelahuntMalaghan Institute of Medical Research, Wellington 6012, New Zealand.
Michael J SorichCollege of Medicine and Public Health, Flinders University, Flinders Drive, Bedford Park, Adelaide, SA 5042, Australia.ORCID 0000-0003-1999-866X
Kim MorettiDiscipline of Surgery, University of Adelaide, Adelaide, SA 5371, Australia.
Lisa M ButlerSouth Australian ImmunoGENomics Cancer Institute and Freemasons Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, SA 5005, Australia.ORCID 0000-0003-2698-3220
John J O'LearyDepartment of Histopathology, Trinity College Dublin, D02 PN40 Dublin, Ireland.ORCID 0000-0001-7311-9326
Douglas A BrooksClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA 5000, Australia.ORCID 0000-0001-9098-3626
University of South Australia · AUCoombe Women & Infants University Hospital · IETrinity College Dublin · IEFlinders University · AUMalaghan Institute of Medical Research · NZRMIT University · AUSouth Australian Health and Medical Research Institute · AUThe University of Queensland · AU

Funding

Cancer Council SA NACancer Council SA PRF1117Envision Sciences NAMTP Connect Biomedical Translation Bridge Program grant BTBR200074National Health and Medical Research Council APP2008119National Health and Medical Research Council GNT1092904University of South Australia NA
6 · The paper itself

Abstract

Gleason scoring is used within a five-tier risk stratification system to guide therapeutic decisions for patients with prostate cancer. This study aimed to compare the predictive performance of routine H&E or biomarker-assisted ISUP (International Society of Urological Pathology) grade grouping for assessing the risk of biochemical recurrence (BCR) and clinical recurrence (CR) in patients with prostate cancer. This retrospective study was an assessment of 114 men with prostate cancer who provided radical prostatectomy samples to the Australian Prostate Cancer Bioresource between 2006 and 2014. The prediction of CR was the primary outcome (median time to CR 79.8 months), and BCR was assessed as a secondary outcome (median time to BCR 41.7 months). The associations of (1) H&E ISUP grade groups and (2) modified ISUP grade groups informed by the Appl1, Sortilin and Syndecan-1 immunohistochemistry (IHC) labelling were modelled with BCR and CR using Cox proportional hazard approaches. IHC-assisted grading was more predictive than H&E for BCR (C-statistic 0.63 vs. 0.59) and CR (C-statistic 0.71 vs. 0.66). On adjusted analysis, IHC-assisted ISUP grading was independently associated with both outcome measures. IHC-assisted ISUP grading using the biomarker panel was an independent predictor of individual BCR and CR. Prospective studies are needed to further validate this biomarker technology and to define BCR and CR associations in real-world cohorts.

Indexed as

biomarkersclinical recurrencediagnosisprognosisprostate cancer

Identifiers

PMID37370825
PMCPMC10296524
OpenAlexW4380992398

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.