Evidence map›Paper›PMID 37370706›Full record

ArticleCancers2023

Immuno-Contexture and Immune Checkpoint Molecule Expression in Mismatch Repair Proficient Colorectal Carcinoma.

Mauro Giacomelli, Matilde Monti, Diego Cesare Pezzola, Silvia Lonardi, Mattia Bugatti, Francesco Missale, Rossella Cioncada, Laura Melocchi, Viviana Giustini, Vincenzo Villanacci and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 4 countries.

Mauro GiacomelliDepartment of Pathology, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Matilde MontiDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Diego Cesare PezzolaDepartment of Surgery, Surgery Division II, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Silvia LonardiDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0003-0307-4163
Mattia BugattiDepartment of Pathology, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Francesco MissaleDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-5357-5348
Rossella CioncadaDepartment of Pathology, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Laura MelocchiDepartment of Pathology, Fondazione Poliambulanza, 25124 Brescia, Italy.ORCID 0000-0001-5161-6305
Viviana GiustiniCREA Laboratory, AIL Center for Hemato-Oncologic Research, Diagnostic Department, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Vincenzo VillanacciDepartment of Pathology, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Carla BaronchelliDepartment of Pathology, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Stefania ManentiDepartment of Pathology, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Luisa ImbertiSection of Microbiology, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-2075-8391
Emanuele GiurisatoDepartment of Biotechnology Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-0598-6449
William VermiDepartment of Pathology, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.ORCID 0000-0002-2291-2997
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITUniversity of Brescia · ITFondazione Poliambulanza Istituto Ospedaliero · ITThe Netherlands Cancer Institute · NLUniversity of Siena · ITWashington University in St. Louis · US

Funding

Italian Association for Cancer Research IG-23179
6 · The paper itself

Abstract

Colorectal carcinoma (CRC) represents a lethal disease with heterogeneous outcomes. Only patients with mismatch repair (MMR) deficient CRC showing microsatellite instability and hyper-mutated tumors can obtain clinical benefits from current immune checkpoint blockades; on the other hand, immune- or target-based therapeutic strategies are very limited for subjects with mismatch repair proficient CRC (CRC

Indexed as

colorectal cancerdouble negative T cellsimmune checkpointinterferon-γmicrosatellite instabilitymismatch repairPD-L1T-cell exhaustiontumor microenvironment

Identifiers

PMID37370706
PMCPMC10296282
OpenAlexW4379882190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.