Evidence map›Paper›PMID 37370696›Full record

ReviewCancers2023

Comparison of Medical Management versus Parathyroidectomy in Patients with Mild Primary Hyperparathyroidism: A Meta-Analysis.

Katherine A Cironi, Peter P Issa, Aaron L Albuck, Christina McCarthy, Leely Rezvani, Mohammad Hussein, Xinyi Luo, Mohamed Shama, Eman Toraih, Emad Kandil

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Katherine A CironiSchool of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0002-6229-672X
Peter P IssaSchool of Medicine, Louisiana State University, New Orleans, LA 70112, USA.ORCID 0000-0002-5248-3142
Aaron L AlbuckSchool of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0003-3683-689X
Christina McCarthySchool of Medicine, Tulane University, New Orleans, LA 70112, USA.
Leely RezvaniSchool of Medicine, Tulane University, New Orleans, LA 70112, USA.
Mohammad HusseinSchool of Medicine, Tulane University, New Orleans, LA 70112, USA.
Xinyi LuoSchool of Medicine, Tulane University, New Orleans, LA 70112, USA.
Mohamed ShamaSchool of Medicine, Tulane University, New Orleans, LA 70112, USA.
Eman ToraihSchool of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0001-9267-3787
Emad KandilSchool of Medicine, Tulane University, New Orleans, LA 70112, USA.
Tulane University · USLouisiana State University · USSuez Canal University · EG

Funding

Tulane University SOM Fall Pilot Grant (to E.T.) and Bridge Fund (to E.K.)
6 · The paper itself

Abstract

backgroundParathyroidectomy is the definitive cure for patients with primary hyperparathyroidism (pHPT) and has an annual prevalence of 0.2-1% in the United States. Some patients with mild disease are medically managed effectively using calcium-lowering medications and drugs against complications such as osteoporosis; however, many maintain a persistently high calcium level that negatively impacts their skeletal, renal, and psychogenic systems over the long term. This meta-analysis aims to compare the outcomes of medical management versus parathyroidectomy in patients with mild pHPT. STUDY

designThis meta-analysis was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using PubMed, Embase, and Web of Science by two teams of investigators. Analysis was run using R packages.

resultsA total of 12 publications including seven randomized control, two prospective, and three retrospective trials with a total of 1346 patients were included for analysis. The average follow-up for all patients was 41 ± 23.8 months. Demographics, pre-treatment calcium, PTH, and bone mineral density (BMD) were similar between the medical (

conclusionsThe present study is the most comprehensive meta-analysis on mild pHPT to date. Our findings reflect that parathyroidectomy is the superior option in the treatment of mild pHPT patients as opposed to medical management.

Indexed as

meta-analysismild primary hyperparathyroidismparathyroidectomy

Identifiers

PMID37370696
PMCPMC10296026
OpenAlexW4379800576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.