Evidence map›Paper›PMID 37370654›Full record

ArticleBioengineering (Basel, Switzerland)2023

Holistic Approach to Process Design and Scale-Up for Itaconic Acid Production from Crude Substrates.

Katharina Maria Saur, Robert Kiefel, Paul-Joachim Niehoff, Jordy Hofstede, Philipp Ernst, Johannes Brockkötter, Jochem Gätgens, Jörn Viell, Stephan Noack, Nick Wierckx and 2 more

Open access · goldAbstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Katharina Maria SaurFluid Process Engineering (AVT.FVT), RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0001-8658-7137
Robert KiefelFluid Process Engineering (AVT.FVT), RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-2264-3379
Paul-Joachim NiehoffBiochemical Engineering (AVT.BioVT), RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0001-6703-4086
Jordy HofstedeProcess Systems Engineering (AVT.SVT), RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-6049-8694
Philipp ErnstForschungszentrum Jülich, Institute of Bio- and Geosciences IBG-1, 52428 Jülich, Germany.ORCID 0000-0001-7902-0634
Johannes BrockkötterFluid Process Engineering (AVT.FVT), RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0003-0029-0012
Jochem GätgensForschungszentrum Jülich, Institute of Bio- and Geosciences IBG-1, 52428 Jülich, Germany.ORCID 0000-0002-9232-180X
Jörn ViellProcess Systems Engineering (AVT.SVT), RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0003-0587-6151
Stephan NoackForschungszentrum Jülich, Institute of Bio- and Geosciences IBG-1, 52428 Jülich, Germany.ORCID 0000-0001-9784-3626
Nick WierckxForschungszentrum Jülich, Institute of Bio- and Geosciences IBG-1, 52428 Jülich, Germany.ORCID 0000-0002-1590-1210
Jochen BüchsBiochemical Engineering (AVT.BioVT), RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-2012-3476
Andreas JupkeFluid Process Engineering (AVT.FVT), RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0001-6551-5695
RWTH Aachen University · DEForschungszentrum Jülich · DE

Funding

Deutsche Forschungsgemeinschaft INST 222/1144-1 FUGBFederal Ministry of Education and Research 031B0918E
6 · The paper itself

Abstract

Bio-based bulk chemicals such as carboxylic acids continue to struggle to compete with their fossil counterparts on an economic basis. One possibility to improve the economic feasibility is the use of crude substrates in biorefineries. However, impurities in these substrates pose challenges in fermentation and purification, requiring interdisciplinary research. This work demonstrates a holistic approach to biorefinery process development, using itaconic acid production on thick juice based on sugar beets with

Indexed as

biorefineryconceptual process designitaconic acidscale-upU. cynodontis

Identifiers

PMID37370654
PMCPMC10295305
OpenAlexW4380997485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.