Evidence map›Paper›PMID 37370635›Full record

ArticleBioengineering (Basel, Switzerland)2023

Dual-Crosslinking of Gelatin-Based Hydrogels: Promising Compositions for a 3D Printed Organotypic Bone Model.

Ahmer Shehzad, Fariza Mukasheva, Muhammad Moazzam, Dana Sultanova, Birzhan Abdikhan, Alexander Trifonov, Dana Akilbekova

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ahmer ShehzadDepartment of Chemical Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Astana 010000, Kazakhstan.
Fariza MukashevaDepartment of Chemical Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Astana 010000, Kazakhstan.
Muhammad MoazzamDepartment of Chemical Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Astana 010000, Kazakhstan.ORCID 0009-0005-9320-2131
Dana SultanovaDepartment of Chemical Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Astana 010000, Kazakhstan.
Birzhan AbdikhanDepartment of Chemical Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Astana 010000, Kazakhstan.
Alexander TrifonovDepartment of Chemical Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Astana 010000, Kazakhstan.ORCID 0000-0003-4924-4180
Dana AkilbekovaDepartment of Chemical Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Astana 010000, Kazakhstan.ORCID 0000-0003-3694-0355

Funding

Ministry of Education and Science of the Republic of Kazakhstan AP13067719Nazarbayev University FDRCG SEDS2020020
6 · The paper itself

Abstract

Gelatin-based hydrogels have emerged as a popular scaffold material for tissue engineering applications. The introduction of variable crosslinking methods has shown promise for fabricating stable cell-laden scaffolds. In this work, we examine promising composite biopolymer-based inks for extrusion-based 3D bioprinting, using a dual crosslinking approach. A combination of carefully selected printable hydrogel ink compositions and the use of photoinduced covalent and ionic crosslinking mechanisms allows for the fabrication of scaffolds of high accuracy and low cytotoxicity, resulting in unimpeded cell proliferation, extracellular matrix deposition, and mineralization. Three selected bioink compositions were characterized and the respective cell-laden scaffolds were bioprinted. Temporal stability, morphology, swelling, and mechanical properties of the scaffolds were thoroughly studied and the biocompatibility of the constructs was assessed using rat mesenchymal stem cells while focusing on osteogenesis. Experimental results showed that the composition of 1% alginate, 4% gelatin, and 5% (

Indexed as

3D bioprintingbone tissue engineeringdual crosslinkinggelatinhydrogel scaffolds

Identifiers

PMID37370635
PMCPMC10295226

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.