ArticleBioengineering (Basel, Switzerland)2023
Enhancement of Antibacterial Properties, Surface Morphology and In Vitro Bioactivity of Hydroxyapatite-Zinc Oxide Nanocomposite Coating by Electrophoretic Deposition Technique.
Article in Bioengineering (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 25 citations in OpenAlex.
- Optimizing Electrochemical Deposition for Biodegradable Zinc-Hydroxyapatite Systems in Bone Repair.ACS omega · 2026Article
- Characterization and biocompatibility evaluation of a Ti@HA-GO@IL-4 bioactive composite coating for guided bone regeneration in dental implant applications.BMC oral health · 2025Article
- Analysis of Conventional and Enhanced-Biocompatibility ZnO/Ag Heterojunction Nanorod-Based Advanced Root Canal Sealers.Bioengineering (Basel, Switzerland) · 2025Article
- Functional Assessment of Microplasma-Sprayed Hydroxyapatite-Zirconium Bilayer Coatings: Mechanical and Biological Perspectives.Materials (Basel, Switzerland) · 2025Article
- Osteogenic Potential of 3D-Printed Porous Poly(lactide-ACS applied materials & interfaces · 2025Article
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Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To develop medical-grade stainless-steel 316L implants that are biocompatible, non-toxic and antibacterial, such implants need to be coated with biomaterials to meet the current demanding properties of biomedical materials. Hydroxyapatite (HA) is commonly used as a bone implant coating due to its excellent biocompatible properties. Zinc oxide (ZnO) nanoparticles are added to HA to increase its antibacterial and cohesion properties. The specimens were made of a stainless-steel grade 316 substrate coated with HA-ZnO using the electrophoretic deposition technique (EPD), and were subsequently characterized using scanning electron microscopy (SEM), energy dispersive X-ray (EDX), stylus profilometry, electrochemical corrosion testing and Fourier transform infrared (FTIR) spectroscopy. Additionally, cross-hatch tests, cell viability assays, antibacterial assessment and in vitro activity tests in simulated body fluid (SBF) were performed. The results showed that the HA-ZnO coating was uniform and resistant to corrosion in an acceptable range. FTIR confirmed the presence of HA-ZnO compositions, and the in vitro response and adhesion were in accordance with standard requirements for biomedical materials. Cell viability confirmed the viability of cells in an acceptable range (>70%). In addition, the antibacterial activity of ZnO was confirmed on Staphylococcus aureus. Thus, the HA-ZnO samples are recommended for biomedical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.