Evidence map›Paper›PMID 37370319›Full record

ArticleAntibiotics (Basel, Switzerland)2023

Antibiotic Treatment Induces Long-Lasting Effects on Gut Microbiota and the Enteric Nervous System in Mice.

Giulia Bernabè, Mahmoud Elsayed Mosaad Shalata, Veronica Zatta, Massimo Bellato, Andrea Porzionato, Ignazio Castagliuolo, Paola Brun

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
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  5. Review
  6. Article
  7. Frequent high-level rifaximin resistance inMicrobiology spectrum · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
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  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giulia BernabèDepartment of Molecular Medicine, University of Padova, Via A. Gabelli, 63-35127 Padova, Italy.
Mahmoud Elsayed Mosaad ShalataDepartment of Molecular Medicine, University of Padova, Via A. Gabelli, 63-35127 Padova, Italy.ORCID 0009-0005-3594-2561
Veronica ZattaDepartment of Molecular Medicine, University of Padova, Via A. Gabelli, 63-35127 Padova, Italy.
Massimo BellatoDepartment of Information Engineering, University of Padova, Via G. Gradenigo, 6-35131 Padova, Italy.ORCID 0000-0001-7428-0656
Andrea PorzionatoDepartment of Neuroscience, University of Padova, Via A. Gabelli, 61-35127 Padova, Italy.
Ignazio CastagliuoloDepartment of Molecular Medicine, University of Padova, Via A. Gabelli, 63-35127 Padova, Italy.
Paola BrunDepartment of Molecular Medicine, University of Padova, Via A. Gabelli, 63-35127 Padova, Italy.ORCID 0000-0002-3279-9000

Funding

University of Padova CPDA128452
6 · The paper itself

Abstract

The side effects of antibiotic treatment directly correlate with intestinal dysbiosis. However, a balanced gut microbiota supports the integrity of the enteric nervous system (ENS), which controls gastrointestinal neuromuscular functions. In this study, we investigated the long-term effects of antibiotic-induced microbial dysbiosis on the ENS and the impact of the spontaneous re-establishment of the gut microbiota on gastrointestinal functions. C57BL/6J mice were treated daily for two weeks with antibiotics. After 0-6 weeks of antibiotics wash-out, we determined (a) gut microbiota composition, (b) gastrointestinal motility, (c) integrity of the ENS, (d) neurochemical code, and (e) inflammation. Two weeks of antibiotic treatment significantly altered gut microbial composition; the genera

Indexed as

antibioticenteric nervous systemgastrointestinal motility disordergut microbiotainflammation

Identifiers

PMID37370319
PMCPMC10295661

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.