Evidence map›Paper›PMID 37370298›Full record

ArticleAntibiotics (Basel, Switzerland)2023

Altered Pharmacokinetics Parameters of Vancomycin in Patients with Hematological Malignancy with Febrile Neutropenia, a Bayesian Software Estimation.

Abdullah M Alzahrani, Anjum Naeem, Aeshah AlAzmi, Alqassem Y Hakami, Shahid Karim, Ahmed S Ali, Fatemah Omer Kamel, Rami M Alzhrani, Teaf S Alkhaldi, Loujayne A Maghrabi and 2 more

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Abdullah M AlzahraniPharmaceutical Care Department, Ministry of National Guard-Health Affairs, Jeddah 22384, Saudi Arabia.ORCID 0000-0002-0893-0304
Anjum NaeemPharmaceutical Care Department, Ministry of National Guard-Health Affairs, Jeddah 22384, Saudi Arabia.
Aeshah AlAzmiPharmaceutical Care Department, Ministry of National Guard-Health Affairs, Jeddah 22384, Saudi Arabia.
Alqassem Y HakamiKing Abdullah International Medical Research Center, Jeddah 21423, Saudi Arabia.
Shahid KarimDepartment of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0001-8305-4394
Ahmed S AliDepartment of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Fatemah Omer KamelDepartment of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Rami M AlzhraniDepartment of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif 21944, Saudi Arabia.ORCID 0000-0003-0530-804X
Teaf S AlkhaldiCollege of Pharmacy, Taif University, Taif 21944, Saudi Arabia.
Loujayne A MaghrabiCollege of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Norah F AlshehriDepartment of Pharmacy, East Jeddah Hospital, Ministry of Health, Jeddah 22253, Saudi Arabia.
Yahya A AlzahraniKing Abdullah International Medical Research Center, Jeddah 21423, Saudi Arabia.
King Saud bin Abdulaziz University for Health Sciences · SAKing Abdulaziz University · SATaif University · SAKing Abdullah International Medical Research Center · SAMinistry of Health · SAUmm al-Qura University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pharmacokinetics of vancomycin vary significantly between specific groups of patients, such as critically ill patients and patients with hematological malignancy (HM) with febrile neutropenia (FN). Recent evidence suggests that the use of the usual standard dose of antibiotics in patients with FN may not offer adequate exposure due to pharmacokinetic variability (PK). Therefore, the purpose of this study is to assess the effect of FN on AUC

Indexed as

augmented renal clearance and vancomycinfebrile neutropenia and augmented renal clearancevancomycin low trough in hematological malignancyvancomycin monitoring in the neutropenic patients

Identifiers

PMID37370298
PMCPMC10295334
OpenAlexW4378717643

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.