ArticleAntibiotics (Basel, Switzerland)2023
Genetic Characterization of Carbapenem-Resistant
Article in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 11 citations in OpenAlex.
- Antibiotic resistance profiles and genomic analysis of Klebsiella pneumoniae ST15 with mcr-1 gene isolated from mink in China.BMC veterinary research · 2026Article
- A Pilot Study ofDiagnostics (Basel, Switzerland) · 2026Article
- Development and Evaluation of a Duplex Lateral Flow Immunoassay for Rapid Detection of KPC and NDM Carbapenemases.Infection and drug resistance · 2026Article
- Comparative genomic insights into multidrug resistance in classical and hypervirulent K. pneumoniae clinical isolates.Scientific reports · 2025Article
- Significant Prevalence of Dual KPC/NDM Carbapenemase-ProducingAntibiotics (Basel, Switzerland) · 2025Article
- Genomic characterization and comparative analysis of antibiotic resistance and virulence in Bangladeshi and global Klebsiella pneumoniae ST48 strains.Journal, genetic engineering & biotechnology · 2025Article
- Outbreak of High-Risk Clone ST323Antibiotics (Basel, Switzerland) · 2025Article
- Polymyxin-resistant hypervirulentFrontiers in microbiology · 2025Article
- Comparison of Carbapenemases and Extended-Spectrum β-Lactamases and Resistance Phenotypes in Hospital- and Community-Acquired Isolates ofMicroorganisms · 2024Article
- Prevalence, Characterization, and Epidemiological Relationships between ESBL and Carbapenemase-ProducingAntibiotics (Basel, Switzerland) · 2024Article
- Predominance of OXA-48 carbapenemase-producingBiomolecules & biomedicine · 2024Article
- Investigation of the susceptibility rates to ceftazidime-avibactam and colistin, clonal relationships, and clinical data of patients with carbapenem-resistantAnnals of Saudi medicineArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCarbapenem-resistant
methodsTwenty-four CRKP isolates recovered during 2018-2022 were included in the study. Next-generation sequencing was performed using the Ion Torrent PGM Platform. The identification of the plasmid content, MLST, and antimicrobial resistance genes, as well as the comparison of multiple genome alignments and the identification of core genome single-nucleotide polymorphism sites, were performed using various bioinformatics software.
resultsThe isolates belonged to eight sequence types: 11, 15, 30, 35, 39, 307, 323, and 512. A variety of carbapenemases (KPC, VIM, NDM, and OXA-48) and resistance genes were detected. CRKP strains shared visually common genomic regions with the reference strain (NTUH-K2044). ST15, ST323, ST39, and ST11 CRKP isolates presented on average 17, 6, 16, and 866 recombined SNPs, respectively. All isolates belonging to ST15, ST323, and ST39 were classified into distinct phylogenetic branches, while ST11 isolates were assigned to a two-subclade branch. For large CRKP sets, the phylogeny seems to change approximately every seven SNPs.
conclusionsThe current study provides insight into the genetic characterization of CRKP isolates in the ICUs of a tertiary hospital. Our results indicate clonal dispersion of ST15, ST323, and ST39 and highly diverged ST11 isolates.
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