Evidence map›Paper›PMID 37370186›Full record

ArticleClinical epigenetics2023

Quantification of hematopoietic stem and progenitor cells by targeted DNA methylation analysis.

Ledio Bocova, Wouter Hubens, Cordula Engel, Steffen Koschmieder, Edgar Jost, Wolfgang Wagner

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ledio BocovaInstitute for Stem Cell Biology, University Hospital of RWTH Aachen, Aachen, Germany.
Wouter HubensInstitute for Stem Cell Biology, University Hospital of RWTH Aachen, Aachen, Germany.
Cordula EngelDepartment of Gynecology and Obstetrics, University Hospital of RWTH Aachen, Aachen, Germany.
Steffen KoschmiederDepartment of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, University Hospital of RWTH Aachen, Aachen, Germany.
Edgar JostDepartment of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, University Hospital of RWTH Aachen, Aachen, Germany.
Wolfgang WagnerInstitute for Stem Cell Biology, University Hospital of RWTH Aachen, Aachen, Germany. wwagner@ukaachen.de.
RWTH Aachen University · DEIntegrated Oncology (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematopoietic stem and progenitor cells (HSPCs) are quantified in daily clinical practice by flow cytometry. In this study, we provide proof of concept that HSPCs can also be estimated by targeted DNA methylation (DNAm) analysis. The DNAm levels at three individual CG dinucleotides (CpG sites) in the genes MYO1D, STK17A, and SP140 correlated with CD34

Indexed as

DNA MethylationLeukemiaAntigens, CD34Apoptosis Regulatory ProteinsGranulocyte Colony-Stimulating FactorHematopoietic Stem CellsHumansProtein Serine-Threonine KinasesAntigens, CD34Apoptosis Regulatory ProteinsGranulocyte Colony-Stimulating FactorProtein Serine-Threonine KinasesSTK17A protein, humanBiomarkerBlastCD34DNA methylationEpigeneticHematopoietic stem cellsHSCLeukemia

Identifiers

PMID37370186
PMCPMC10303729
OpenAlexW4382239596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.