Evidence map›Paper›PMID 37369931›Full record

ArticleIrish journal of medical science2024

NR_103776.1 as a novel diagnostic biomarker for systemic lupus erythematosus.

Yuqun Wang, Jia He, Honglei Ma, Junhong Liu, Linping Du, Chunxiang Chai, Yajing Liu, Xiaodong Wang

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In one paragraph

Article in Irish journal of medical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yuqun WangDepartment of Rheumatology and Immunology, School of Clinical Medicine, Affiliated Hospital of Weifang Medical University, Weifang Medical University, Weifang, Shandong Province, China.
Jia HeDepartment of Rheumatology and Immunology, School of Clinical Medicine, Affiliated Hospital of Weifang Medical University, Weifang Medical University, Weifang, Shandong Province, China.
Honglei MaDepartment of Rheumatology and Immunology, School of Clinical Medicine, Affiliated Hospital of Weifang Medical University, Weifang Medical University, Weifang, Shandong Province, China.
Junhong LiuDepartment of Rheumatology and Immunology, School of Clinical Medicine, Affiliated Hospital of Weifang Medical University, Weifang Medical University, Weifang, Shandong Province, China.
Linping DuDepartment of Rheumatology and Immunology, School of Clinical Medicine, Affiliated Hospital of Weifang Medical University, Weifang Medical University, Weifang, Shandong Province, China.
Chunxiang ChaiDepartment of Rheumatology and Immunology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong Province, China.
Yajing LiuDepartment of Rheumatology and Immunology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong Province, China.
Xiaodong WangDepartment of Rheumatology and Immunology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong Province, China. wxdongdoctor@163.com.ORCID http://orcid.org/0000-0002-7380-3803
Weifang Medical University · CN

Funding

Natural Science Foundation of Shandong Province ZR2017LH039Science and Technology Service Network Plan of Weifang WFZYY2022-4-026
6 · The paper itself

Abstract

backgroundWith the development of sequencing technologies, there is increasing evidence that long noncoding RNAs (lncRNAs) are involved in systemic lupus erythematosus (SLE). The level of NR_103776.1 expression in SLE and its clinical associations are still not well defined.

objectiveTo identify differentially expressed lncRNAs and explore their functional roles in SLE.

methodsTranscriptome sequencing was used to screen differentially expressed lncRNAs and mRNAs. Expression validation of clinical samples was performed by QRT-PCR. Bioinformatics was used to analyze its prognostic value and potential function.

resultsOf the 231 significantly differentially expressed lncRNAs, NR_103776.1 could be used to distinguish not only SLE patients and rheumatoid arthritis patients but also active SLE patients, stable SLE patients, and healthy controls. NR_103776.1 was significantly and negatively correlated with inflammatory indexes (CRP and ESR). NR_103776.1 dysregulation might contribute to the metabolism of RNA and proteins in SLE patients.

conclusionsThis study not only provided a transcriptome profile of lncRNAs aberrantly expressed in individual nucleated cells of SLE patients but also suggested NR_103776.1 as a novel potential diagnostic biomarker.

Indexed as

Lupus Erythematosus, SystemicRNA, Long NoncodingBiomarkersGene Expression ProfilingHumansLeukocytes, MononuclearRNA, MessengerBiomarkersRNA, Long NoncodingRNA, MessengerBiomarkerEpigenetic regulationlncRNA NR_103776.1Systemic lupus erythematosusTranscriptome sequencing

Identifiers

PMID37369931
OpenAlexW4382197457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.