ArticleNature communications2023
Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- High-dose Vitamin-B6 reduces sensory over-responsivity.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Mechanisms of Selective Serotonin Reuptake Inhibitors in Treatment-Resistant Obsessive-Compulsive Disorder: Cortico-Striatal Circuitry, Glutamatergic Dysregulation, and Neuroplastic Constraints.Molecular neurobiology · 2026Review
- Impaired midfrontal‑motor theta phase synchronization characterizes maladaptive motivational behavior in people with obsessive‑compulsive disorder.PLoS biology · 2026Article
- Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder.Nature communications · 2026Article
- Cognitive engagement induces area-specific fingerprints of dopamine, acetylcholine, serotonin, glutamate and GABA in prefrontal cortex and striatum.bioRxiv : the preprint server for biology · 2026Article
- Functional connectivity density alterations in obsessive-compulsive disorder are associated with neurotransmitter and genetic profiles.Translational psychiatry · 2026Article
- Digital Twin Brain simulation and manipulation of a functional brain network underlying mental illness.bioRxiv : the preprint server for biology · 2026Article
- Metabolic differences in female adolescents with obsessive-compulsive disorder and trichotillomania: insights from plasma untargeted metabolomic analysis.BMC psychiatry · 2026Article
- Age-dependent alterations in anterior cingulate excitation-inhibition balance in major depressive disorder revealed by 7-Tesla magnetic resonance spectroscopy.NeuroImage. Clinical · 2026Article
- GABAFrontiers in pharmacology · 2026Review
- Unexpected Improvement of Obsessive-Compulsive Disorder Symptoms Following the Mistaken Prescription of Clomiphene: A Novel Perspective on Hormonal Influences in OCD.Case reports in psychiatry · 2026Article
- Differences in brain functioning between obsessive-compulsive disorder and generalized anxiety disorder: a clinical study using functional near-infrared spectroscopy.Frontiers in psychiatry · 2026Article
- The consequences of using statistical tests on proxy measurements in place of gold standard measurements: an application to magnetic resonance spectroscopy.Scientific reports · 2025Article
- Psilocybin and Obsessive-Compulsive Disorder: Exploring New Therapeutic Horizons.Neuroscience bulletin · 2025Article
- Pain Neuroscience Education on Reducing Opioid Dependency in African American and Caucasian Populations: A Narrative Review.Journal of clinical medicine · 2025Review
- Frontostriatal salience network expands as executive networks contract in Obsessive-Compulsive Disorder.bioRxiv : the preprint server for biology · 2025Article
- The neuropsychological profile of SSADH deficiency, a neurotransmitter disorder of GABA metabolism.Molecular genetics and metabolism · 2025Article
- Ketogenic diet as a therapeutic intervention for obsessive-compulsive disorder: a case series of three patients.Frontiers in nutrition · 2025Article
- The Etiology, Assessment and Treatment of Compulsive Checking: A Review.Psychology research and behavior management · 2025Review
- Age-related GABA- and glutamatergic differences in SMA during bimanual coordination.Imaging neuroscience (Cambridge, Mass.) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 3 countries.
Funding
Abstract
There has been little analysis of neurochemical correlates of compulsive behaviour to illuminate its underlying neural mechanisms. We use 7-Tesla proton magnetic resonance spectroscopy (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.