Evidence map›Paper›PMID 37369681›Full record

ReviewCell death discovery2023

Emerging roles of ferroptosis-related miRNAs in tumor metastasis.

Zhongyi Jiang, Jing Zhou, Junqi Deng, Luohong Li, Ruifeng Wang, Yingying Han, Junyu Zhou, Rui Tao, Lushan Peng, Dan Wang and 6 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell death discovery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 2 countries.

Zhongyi Jiang *Department of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China.
Jing Zhou *Department of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China.
Junqi DengDepartment of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China.
Luohong LiDepartment of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China.
Ruifeng WangDepartment of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China.
Yingying HanDepartment of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China.
Junyu ZhouDepartment of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China.
Rui TaoDepartment of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China.
Lushan PengDepartment of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China.
Dan WangDepartment of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China.
Tao HuangDepartment of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China.
Yupei YuDepartment of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China.
Zongjiang ZhouDepartment of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China.
Jinghe LiDepartment of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China.
Diabate OusmaneDepartment of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China.
Junpu WangDepartment of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China. wang-jp2013@csu.edu.cn.ORCID http://orcid.org/0000-0002-3193-1268
Central South University · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81602167
6 · The paper itself

Abstract

Ferroptosis, a novel mode of cell death dependent on iron and reactive oxygen species, has been extensively explored during malignant tumors metastasis. Ferroptosis can interact with multiple components of the tumor microenvironment to regulate metastasis. These interactions generally include the following aspects: (1) Epithelial-mesenchymal transformation, which can help cancer cells increase their sensitivity to ferroptosis while they have multiple mechanisms to fight against it; (2) Disorder of iron metabolism in cancer stem cells which maintains their stem characteristics; (3) Polarization of M0 macrophages to M2. (4) The paradoxical effects of iron metabolism and CD8 + T cells induced by ferroptosis (5) Regulation of angiogenesis. In addition, ferroptosis can be regulated by miRNAs through the reprogramming of various intracellular metabolism processes, including the regulation of the glutathione- glutathione peroxidase 4 pathway, glutamic acid/cystine transport, iron metabolism, lipid metabolism, and oxidative stress. Therefore, there are many potential interactions between ferroptosis-related miRNAs and tumor metastasis, including interaction with cancer cells and immune cells, regulating cytokines, and angiogenesis. This review focuses on the role of ferroptosis-related miRNA in tumor metastasis, aiming to help readers understand their relationship and provide a new perspective on the potential treatment strategies of malignant tumors.

Identifiers

PMID37369681
PMCPMC10300116
OpenAlexW4382344618

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.