Evidence map›Paper›PMID 37369523›Full record

ArticleCMAJ open

Hot weather and death related to acute cocaine, opioid and amphetamine toxicity in British Columbia, Canada: a time-stratified case-crossover study.

Sarah B Henderson, Kathleen E McLean, Yue Ding, Jiayun Yao, Nikita Saha Turna, David McVea, Tom Kosatsky

Open access · diamondAbstract read
In one paragraph

Article in CMAJ open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Socioenvironmental disasters and the dialectics of overdose mortality.The International journal on drug policy · 2026
    Article
  2. Article
  3. Heat exposure and drug overdose mortality in the USA.Addiction (Abingdon, England) · 2026
    Observational
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Sarah B HendersonEnvironmental Health Services (Henderson, McLean, Yao, Saha Turna, McVea, Kosatsky), BC Centre for Disease Control; School of Population and Public Health (Henderson, Ding, McVea, Kosatsky), University of British Columbia, Vancouver, BC sarah.henderson@bccdc.ca.
Kathleen E McLeanEnvironmental Health Services (Henderson, McLean, Yao, Saha Turna, McVea, Kosatsky), BC Centre for Disease Control; School of Population and Public Health (Henderson, Ding, McVea, Kosatsky), University of British Columbia, Vancouver, BC.
Yue DingEnvironmental Health Services (Henderson, McLean, Yao, Saha Turna, McVea, Kosatsky), BC Centre for Disease Control; School of Population and Public Health (Henderson, Ding, McVea, Kosatsky), University of British Columbia, Vancouver, BC.
Jiayun YaoEnvironmental Health Services (Henderson, McLean, Yao, Saha Turna, McVea, Kosatsky), BC Centre for Disease Control; School of Population and Public Health (Henderson, Ding, McVea, Kosatsky), University of British Columbia, Vancouver, BC.
Nikita Saha TurnaEnvironmental Health Services (Henderson, McLean, Yao, Saha Turna, McVea, Kosatsky), BC Centre for Disease Control; School of Population and Public Health (Henderson, Ding, McVea, Kosatsky), University of British Columbia, Vancouver, BC.
David McVeaEnvironmental Health Services (Henderson, McLean, Yao, Saha Turna, McVea, Kosatsky), BC Centre for Disease Control; School of Population and Public Health (Henderson, Ding, McVea, Kosatsky), University of British Columbia, Vancouver, BC.
Tom KosatskyEnvironmental Health Services (Henderson, McLean, Yao, Saha Turna, McVea, Kosatsky), BC Centre for Disease Control; School of Population and Public Health (Henderson, Ding, McVea, Kosatsky), University of British Columbia, Vancouver, BC.
The Centre for Health (New Zealand) · NZBC Centre for Disease Control · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious research has shown that cocaine-associated deaths occur more frequently in hot weather, which has not been described for other illicit drugs or combinations of drugs. The study objective was to evaluate the relation between temperature and risk of death related to cocaine, opioids and amphetamines in British Columbia, Canada.

methodsWe extracted data on all deaths with cocaine, opioid or amphetamine toxicity recorded as an underlying or contributing cause from BC vital statistics for 1998-2017. We used a time-stratified case-crossover design to estimate the effect of temperature on the risk of death associated with acute drug toxicity during the warmer months (May through September). Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for each 10°C increase in the 2-day average maximum temperature at the residential location.

resultsWe included 4913 deaths in the analyses. A 10°C increase in the 2-day average maximum temperature was associated with an OR of 1.43 (95% CI 1.11-1.86) for deaths with only cocaine toxicity recorded (

interpretationIncreasing temperatures were associated with higher odds of death due to drug toxicity, especially for cocaine alone and combined with other drugs. Targeted interventions are necessary to prevent death associated with toxic drug use during hot weather.

Indexed as

CocaineDrug-Related Side Effects and Adverse ReactionsAnalgesics, OpioidBritish ColumbiaCross-Over StudiesHumansTemperatureAnalgesics, OpioidCocaine

Identifiers

PMID37369523
PMCPMC10310343
OpenAlexW4382243563

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.