Evidence map›Paper›PMID 37369489›Full record

SynthesisIn vivo (Athens, Greece)

Awake Breast Surgery: A Systematic Review.

Gianluca Vanni, Giacomo Costanzo, Marco Pellicciaro, Marco Materazzo, Chiara Buonomo, Tacconi Federico, Erica Giacobbi, Francesca Servadei, Lucia Anemona, Annalisa Noce and 2 more

Open access · diamondAbstract readSystematic Review
In one paragraph

Synthesis in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. PAX Family, Master Regulator in Cancer.Diagnostics (Basel, Switzerland) · 2025
    Review
  7. Wide Awake Breast Reduction.Plastic and reconstructive surgery. Global open · 2025
    Article
  8. Observational
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Gianluca VanniBreast Unit, Department of Surgical Science, PTV Policlinico Tor Vergata University, Rome, Italy.
Giacomo CostanzoBreast Unit, Department of Surgical Science, PTV Policlinico Tor Vergata University, Rome, Italy.
Marco PellicciaroBreast Unit, Department of Surgical Science, PTV Policlinico Tor Vergata University, Rome, Italy; marcopell62@gmail.com.
Marco MaterazzoBreast Unit, Department of Surgical Science, PTV Policlinico Tor Vergata University, Rome, Italy.
Chiara BuonomoDepartment of Emergency and Admission, Critical Care Medicine, Pain Medicine and Anesthetic Science, Policlinico Tor Vergata University, Rome, Italy.
Tacconi FedericoDivision of Thoracic Surgery, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy.
Erica GiacobbiAnatomic Pathology, Department of Experimental Medicine, Policlinico Tor Vergata University, Rome, Italy.
Francesca ServadeiAnatomic Pathology, Department of Experimental Medicine, Policlinico Tor Vergata University, Rome, Italy.
Lucia AnemonaAnatomic Pathology, Department of Experimental Medicine, Policlinico Tor Vergata University, Rome, Italy.
Annalisa NoceUOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Mario DauriDepartment of Emergency and Admission, Critical Care Medicine, Pain Medicine and Anesthetic Science, Policlinico Tor Vergata University, Rome, Italy.
Oreste Claudio BuonomoBreast Unit, Department of Surgical Science, PTV Policlinico Tor Vergata University, Rome, Italy.
Policlinico Tor Vergata · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimAwake surgery has become a valid alternative to general anesthesia in many surgery fields. This technique played a very important role during the COVID-19 period. The growing use of this technique has many advantages. We performed a systematic review to study the potentialities of awake breast surgery. MATERIALS AND

methodsWe searched Pubmed, Embase, and Cochrane library database and retrieved a total of 109 records. Forty-nine of them were excluded as unsuitable. Finally, we selected a total of 12 records concerning different types of studies for topic appropriateness. Three reviewers reviewed independently each record.

resultsFive articles analyzing the sustainability of awake surgery during the COVID-19 period were selected. In addition, one article analyzing the impact on the immune system and six articles and eight case reports analyzing anesthetic techniques were also selected. The studies analyzing awake breast surgery during the COVID-19 period showed advantages in terms of sustainability and length of hospitalization. The study analyzing the immune response after awake breast surgery showed lesser lymphocyte response than the general anesthesia group. The studies analyzing anesthetic techniques in awake breast surgery showed that the nerve blocks allow good level of safety and postoperative pain control.

conclusionThe awake breast surgery and fast track implementation shortened hospital stays and reduced costs, without influencing the surgical results. Furthermore, awake breast surgery reduced surgical stress compared to general anesthesia. Among the various anesthetic techniques, nerve blocks are the most advantageous in terms of safety and efficacy compared to epidural anesthesia.

Indexed as

Brain NeoplasmsBreast NeoplasmsCOVID-19Nerve BlockFemaleHumansWakefulnessAwake breast surgeryawake surgeryreviewsurgery without patient intubation

Identifiers

PMID37369489
PMCPMC10347915
OpenAlexW4382241217

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.