Evidence map›Paper›PMID 37369263›Full record

ArticleChemico-biological interactions2023

Impact of phenanthrene co-administration on the toxicokinetics of benzo[a]pyrene in humans. UPLC-accelerator mass spectrometry following oral microdosing.

Monica L Vermillion Maier, Lisbeth K Siddens, Jamie M Pennington, Sandra L Uesugi, Edwin M Labut, Emily A Vertel, Kim A Anderson, Lane G Tidwell, Susan C Tilton, Ted J Ognibene and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemico-biological interactions, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Identification and Quantitation ofMethods and protocols · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Monica L Vermillion MaierLinus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 97331, USA. Electronic address: monica.maier@oregonstate.edu.
Lisbeth K SiddensLinus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 97331, USA. Electronic address: beth.siddens@oregonstate.edu.
Jamie M PenningtonLinus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 97331, USA. Electronic address: jamie.pennington@oregonstate.edu.
Sandra L UesugiLinus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA. Electronic address: sandra.uesugi@oregonstate.edu.
Edwin M LabutLinus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA. Electronic address: Ed.Labut@oregonstate.edu.
Emily A VertelLinus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA. Electronic address: vertele@oregonstate.edu.
Kim A AndersonDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 97331, USA; NIEHS Superfund Research Program, Oregon State University, Corvallis, OR, 97331, USA. Electronic address: kim.anderson@oregonstate.edu.
Lane G TidwellDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 97331, USA. Electronic address: lane.tidwell@oregonstate.edu.
Susan C TiltonDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 97331, USA; NIEHS Superfund Research Program, Oregon State University, Corvallis, OR, 97331, USA. Electronic address: susan.tilton@oregonstate.edu.
Ted J OgnibeneCenter for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, Livermore, CA, 94550, USA. Electronic address: ognibene1@llnl.gov.
Kenneth W TurteltaubCenter for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, Livermore, CA, 94550, USA; Biology and Biotechnology Research Division, Lawrence Livermore National Laboratory, Livermore, CA, 94550, USA. Electronic address: turteltaub2@llnl.gov.
Jordan N SmithNIEHS Superfund Research Program, Oregon State University, Corvallis, OR, 97331, USA; Chemical Biology and Exposure Science, Pacific Northwest National Laboratory, Richland, WA, 99354, USA. Electronic address: jordan.smith@pnnl.gov.
David E WilliamsLinus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 97331, USA; NIEHS Superfund Research Program, Oregon State University, Corvallis, OR, 97331, USA.
Oregon State University · USLawrence Livermore National Laboratory · US

Funding

Research Experience and Training Coordination CoreP42ES016465 · NIEHS · OREGON STATE UNIVERSITY · PI Robyn L Tanguay · 2009 to 2026
$52.5M
MODE OF ACTION OF ENVIRONMENTAL TOXICANTST32ES007060 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt, Siva Kumar Kolluri · 1985 to 2026
$11.6M
Zebrafish Biomedical Research Facility CoreP30ES030287 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt · 2020 to 2026
$9.8M
National User Resource for Biological Accelerator Mass SpectrometryR24GM137748 · NIGMS · LAWRENCE LIVERMORE NATIONAL SECURITY, LLC · PI BENCH, GRAHAM · 2020 to 2024
$6.5M
Benzo[a]pyrene Micro-dosing of Humans: A New Tool for Exposure, Risk Assessment and PreventionR01ES028600 · NIEHS · OREGON STATE UNIVERSITY · PI WILLIAMS, DAVID E · 2018 to 2022
$2.5M
NIEHS NIH HHS P30 ES030287NIEHS NIH HHS P42 ES016465NIEHS NIH HHS R01 ES028600NIEHS NIH HHS T32 ES007060NIGMS NIH HHS R24 GM137748
6 · The paper itself

Abstract

Current risk assessments for environmental carcinogens rely on animal studies utilizing doses orders of magnitude higher than actual human exposures. Epidemiological studies of people with high exposures (e.g., occupational) are of value, but rely on uncertain exposure data. In addition, exposures are typically not to a single chemical but to mixtures, such as polycyclic aromatic hydrocarbons (PAHs). The extremely high sensitivity of accelerator mass spectrometry (AMS) allows for dosing humans with known carcinogens with de minimus risk. In this study UPLC-AMS was used to assess the toxicokinetics of [

Indexed as

PhenanthrenesPolycyclic Aromatic HydrocarbonsAnimalsBenzo(a)pyreneHumansMass SpectrometryToxicokineticsBenzo(a)pyrenephenanthrenePhenanthrenesPolycyclic Aromatic HydrocarbonsBenzo[a]pyreneHuman micro-dosingPhenanthrenePolycyclic aromatic hydrocarbon mixturesUPLC-Accelerator mass spectrometry

Identifiers

PMID37369263
PMCPMC10782561
OpenAlexW4381953040

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.