ArticleToxics2023
Two Different Heated Tobacco Products vs. Cigarettes: Comparison of Nicotine Delivery and Subjective Effects in Experienced Users.
Article in Toxics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Assessment of Abuse Liability and Nicotine Pharmacokinetics of glo Heated Tobacco Products in a Randomized, Crossover Study.European journal of drug metabolism and pharmacokinetics · 2024Trial
- Heated tobacco product awareness and use following New Zealand's excise tax reduction on these products: A cross-sectional survey of adults who smoke tobacco.Preventive medicine reports · 2026Article
- Nicotine: evolution, dependence, and the path to total quit: redefining cessation in a changing nicotine landscape.Frontiers in public health · 2026Review
- Short-term cardiovascular effects and puffing behavior of exclusive heated tobacco product (HTP) users: A quasi-experimental study.Tobacco induced diseases · 2026Article
- Switching from cigarettes to IQOS: the relative importance of IQOS-associated reward, reinforcement and abstinence relief.Tobacco control · 2025Article
- Article
- Stability Evaluation Method and Application of Puff-by-Puff Release of Aerosol Constituents in Heated Tobacco Materials and Products.ACS omega · 2025Article
- A secondary analysis of the effects of IQOS use on cigarette smoking: Do the effects differ by sex?Drug and alcohol dependence · 2025Article
- Exposure to Toxic Compounds Using Alternative Smoking Products: Analysis of Empirical Data.International journal of environmental research and public health · 2025Article
- Disposable e-cigarettes and their nicotine delivery, usage pattern, and subjective effects in occasionally smoking adults.Scientific reports · 2025Article
- Shifts in motivation to quit cigarette smoking associated with IQOS use.Addictive behaviors · 2025Article
- Evaluating the Effects of Cigarette Smoking and Heated Tobacco Products on Hard Dental Tissues: A Comparative Histological and Colorimetric Analysis.Clinical and experimental dental research · 2024Article
- Cytotoxic impact of nicotine products on periodontal ligament cells.Clinical oral investigations · 2024Article
- Review
- Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives.Journal of xenobiotics · 2024Article
- Cerebral Cortical Vasodilation via Nicotinic Receptors by Heated Tobacco Product Aerosol Extract in Rats.Journal of vascular research · 2024Article
- Influence of anionic species on the low temperature pyrolysis performance of heated tobacco sheets catalyzed by sodium salts.Frontiers in chemistry · 2024Article
- Use of quantitativeFrontiers in toxicology · 2024Article
- Article
- Usage Pattern and Nicotine Delivery during Ad Libitum Consumption of Pod E-Cigarettes and Heated Tobacco Products.Toxics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heated tobacco products (HTPs) produce aerosol using a different mechanism than tobacco cigarettes, leading to lower emissions of some harmful substances, but also of nicotine as reported by some independent studies. Lower nicotine delivery could lead to compensatory puffing when product use does not sufficiently satisfy cravings. Thus, this three-arm crossover study was conducted to characterize the potential of two different HTPs to deliver nicotine and satisfy cravings compared with conventional cigarettes in users who had already switched to HTPs. Fifteen active, non-exclusive HTP users consumed the study products according to a pre-directed puffing protocol. At predetermined time points, venous blood was sampled and the subjective effects of consumption were assessed. Nicotine delivery by both HTPs was comparable, but significantly lower than that by conventional cigarettes, suggesting a lower addictive potential. Cravings were reduced by all products, with no statistically significant differences between them, despite the different nicotine deliveries. This indicated that HTPs do not necessarily need high nicotine deliveries with high addictive potential, as are characteristic of tobacco cigarettes. These results were followed up on with an ad libitum use study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.