Evidence map›Paper›PMID 37368581›Full record

ArticleToxics2023

Individual Risk Assessment for Population Living on the Territories Long-Term Polluted by Organochlorine Pesticides.

Aleksandr Garshin, Nazym Altynova, Erika Djangalina, Ozada Khamdiyeva, Gulminyam Baratzhanova, Anar Tolebaeva, Zhasulan Zhaniyazov, Elmira Khussainova, Céline Cakir-Kiefer, Stefan Jurjanz and 2 more

Open access · goldAbstract read
In one paragraph

Article in Toxics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Aleksandr GarshinInstitute of Genetics and Physiology, Al-Farabi Avenue, 93, Almaty 050060, Kazakhstan.ORCID 0000-0003-3922-0783
Nazym AltynovaInstitute of Genetics and Physiology, Al-Farabi Avenue, 93, Almaty 050060, Kazakhstan.ORCID 0000-0003-3239-2822
Erika DjangalinaInstitute of Genetics and Physiology, Al-Farabi Avenue, 93, Almaty 050060, Kazakhstan.ORCID 0000-0002-1884-0732
Ozada KhamdiyevaInstitute of Genetics and Physiology, Al-Farabi Avenue, 93, Almaty 050060, Kazakhstan.ORCID 0000-0002-3990-4512
Gulminyam BaratzhanovaInstitute of Genetics and Physiology, Al-Farabi Avenue, 93, Almaty 050060, Kazakhstan.ORCID 0000-0002-3542-9881
Anar TolebaevaInstitute of Genetics and Physiology, Al-Farabi Avenue, 93, Almaty 050060, Kazakhstan.
Zhasulan ZhaniyazovInstitute of Genetics and Physiology, Al-Farabi Avenue, 93, Almaty 050060, Kazakhstan.
Elmira KhussainovaInstitute of Genetics and Physiology, Al-Farabi Avenue, 93, Almaty 050060, Kazakhstan.
Céline Cakir-KieferINRAE, URAFPA, Université de Lorraine, F-54000 Nancy, France.ORCID 0000-0002-4630-0864
Stefan JurjanzINRAE, URAFPA, Université de Lorraine, F-54000 Nancy, France.
Matthieu DelannoyINRAE, URAFPA, Université de Lorraine, F-54000 Nancy, France.ORCID 0000-0002-9699-6513
Leyla DjansugurovaInstitute of Genetics and Physiology, Al-Farabi Avenue, 93, Almaty 050060, Kazakhstan.ORCID 0000-0002-6745-9903
Al-Farabi Kazakh National University · KZInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement · FR

Funding

Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan AP09260631 "Study of gene polymorphisms responsible for antioxidant protection and immune response in individuals exposed by pesticides for a long time"
6 · The paper itself

Abstract

The long-term storage of unutilized pesticides raised new problems of long-term environmental contamination. The study presents the results of surveying 151 individuals in 7 villages living close to pesticide-contaminated localities. All individuals have been surveyed concerning their consumption habits and lifestyle characteristics. An assessment of the general exposure risks of the local population was carried out using the analysis of pollutants in food products and the average levels of their consumption in the region. The cohort risk evaluation revealed that the greatest risk was associated with the regular consumption of cucumbers, pears, bell peppers, meat, and milk. The new model to estimate individual risks of long-term pesticide pollution was proposed as a calculation of the combined action of 9 risk factors, including individual genotypes, age, lifestyle, and personal pesticide consumption rates. The analysis of the predictive ability of this model showed that the final score for individual health risks corresponded to the development of chronic diseases. A high level of chromosomal aberrations was evidenced for individual genetic risk manifestations. The combined influence of all risk factors revealed contributions of 24.7% for health status and 14.2% for genetic status, while other impacts go to all unaccounted factors.

Indexed as

chromosome aberrationscytogenetic analysisexposure surveyfood habitsmolecular genetic analysispesticides

Identifiers

PMID37368581
PMCPMC10304191
OpenAlexW4378377467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.