Evidence map›Paper›PMID 37368578›Full record

ArticleToxics2023

Lipidomics Analysis Explores the Mechanism of Renal Injury in Rat Induced by 3-MCPD.

Tao Wei, Na Cao, Tiantian Han, Yi Chen, Xingtao Zhou, Liyang Niu, Wenting Liu, Chang Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tao WeiState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.ORCID 0000-0003-2056-7082
Na CaoState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Tiantian HanState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Yi ChenState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Xingtao ZhouState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Liyang NiuState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Wenting LiuState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Chang LiState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.ORCID 0000-0001-7023-8645
Nanchang University · CN

Funding

National Natural Science Foundation of China 31760443National Natural Science Foundation of China 31960505National Research and Development Project 2019YFE0106000Special Project of Science and Technology Cooperation of Jiangxi Province-Science and Technology Cooperation with Developed Countries (key Project) 20212BDH80001
6 · The paper itself

Abstract

3-monochloropropane-1,2-diol (3-MCPD) is a food-process toxic substance, and its main target organ is the kidney. The present study examined and characterized the nephrotoxicity and the lipidomic mechanisms in a model of kidney injury in Sprague Dawley (SD) rats treated with high (45 mg/kg) and low (30 mg/kg) doses of 3-MCPD. The results showed that the ingestion of 3-MCPD led to a dose-dependent increase in serum creatinine and urea nitrogen levels and histological renal impairment. The oxidative stress indicators (MDA, GSH, T-AOC) in the rat kidney altered in a dose-dependent manner in 3-MCPD groups. The lipidomics analysis revealed that 3-MCPD caused kidney injury by interfering with glycerophospholipid metabolism and sphingolipid metabolism. In addition, 38 lipids were screened as potential biomarkers. This study not only revealed the mechanism of 3-MCPD renal toxicity from the perspective of lipidomics but also provided a new approach to the study of 3-MCPD nephrotoxicity.

Indexed as

3-MCPDbiomarkerslipidomicsnephrotoxicitypathway

Identifiers

PMID37368578
PMCPMC10301636
OpenAlexW4378472726

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.