Evidence map›Paper›PMID 37368331›Full record

ReviewNeurology international2023

Gut Microbiota and Its Repercussion in Parkinson's Disease: A Systematic Review in Occidental Patients.

Ana Cristina Proano, Javier A Viteri, Eileen N Orozco, Marco Antonio Calle, Stefany Carolina Costa, Daniel V Reyes, Melissa German-Montenegro, David F Moncayo, Andrea C Tobar, Juan A Moncayo

Abstract readReview
In one paragraph

Review in Neurology international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Branched-chain amino acids ameliorate CD4NPJ Parkinson's disease · 2026
    Article
  7. Article
  8. Nutrients · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
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  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ana Cristina ProanoSchool of Medicine, Universidad Internacional del Ecuador, Quito 170411, Ecuador.ORCID 0009-0008-2373-7116
Javier A ViteriSchool of Medicine, Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Cumbayá 170901, Ecuador.
Eileen N OrozcoSchool of Medicine, Pontificia Universidad Católica del Ecuador, Quito 170143, Ecuador.
Marco Antonio CalleSchool of Medicine, Universidad Católica de Santiago de Guayaquil, Guayaquil 090615, Ecuador.ORCID 0000-0002-1133-8336
Stefany Carolina CostaSchool of Medicine, Pontificia Universidad Católica del Ecuador, Quito 170143, Ecuador.
Daniel V ReyesSchool of Medicine, Universidad Internacional del Ecuador, Quito 170411, Ecuador.
Melissa German-MontenegroSchool of Medicine, Pontificia Universidad Católica del Ecuador, Quito 170143, Ecuador.
David F MoncayoDepartment of Gastroenterology, Pontificia Universidad Católica del Ecuador, Quito 170143, Ecuador.
Andrea C TobarSchool of Medicine, Pontificia Universidad Católica del Ecuador, Quito 170143, Ecuador.
Juan A MoncayoDepartment of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX 79439, USA.ORCID 0000-0003-1547-8747

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Parkinson's disease (PD) is a relatively common and complex pathology, and some of its mechanisms remain to be elucidated. Change in host microbiota is related to the pathophysiology of numerous diseases. This systematic review aims to gather existing data on the occidental hemisphere, compare it, and search for any significant association between Parkinson's disease and gut microbiota dysbiosis. (2) Methods: Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) and Meta-analyses Of Observational Studies in Epidemiology (MOOSE) protocols were used for this systematic review. PubMed was used as the database search engine. Of the 166 studies found, only 10 were used, as they met our inclusion criteria: case-control studies, studies that assessed the correlation of PD and gut microbiome, studies that took place in occidental regions, and studies that were performed on humans and were written in English. The Newcastle-Ottawa Scale was used as the assessment tool for overall risk of bias in this systematic review. (3) Results: The studies analyzed were divided into three geographic areas: Region 1: United States of America and Canada; Region 2: Germany, Ireland, and Finland; and Region 3: Italy; based on geographical similarities among these populations. The following statistically significant results were described in PD patients, compared with non-PD controls. In the first region, a significant increase in the following bacteria was seen: 1. Phylum: Actinobacteriota and its Genus:

Indexed as

Brain-Gut Axisdysbiosisgutmicrobiomemicrobiotaoccidental regionsParkinson’s diseaseshort-chain fatty acids

Identifiers

PMID37368331
PMCPMC10300807

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.