Evidence map›Paper›PMID 37368234›Full record

ReviewSports medicine (Auckland, N.Z.)2023

"Heads Up" for Creatine Supplementation and its Potential Applications for Brain Health and Function.

Darren G Candow, Scott C Forbes, Sergej M Ostojic, Konstantinos Prokopidis, Matt S Stock, Kylie K Harmon, Paul Faulkner

Erratum issuedOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Sports medicine (Auckland, N.Z.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.

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  16. Creatine in women's health: bridging the gap from menstruation through pregnancy to menopause.Journal of the International Society of Sports Nutrition · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 4 countries.

Darren G CandowAging Muscle & Bone Health Laboratory, Faculty of Kinesiology & Health Studies, University of Regina, 3737 Wascana Parkway, Regina, SK, S4S 0A2, Canada. Darren.Candow@uregina.ca.
Scott C ForbesDepartment of Physical Education Studies, Brandon University, Brandon, MB, Canada.
Sergej M OstojicDepartment of Nutrition and Public Health, University of Agder, Kristiansand, Norway.
Konstantinos ProkopidisDepartment of Musculoskeletal Biology, University of Liverpool, Liverpool, UK.
Matt S StockSchool of Kinesiology and Rehabilitation Sciences, University of Central Florida, Orlando, FL, USA.
Kylie K HarmonDepartment of Exercise Science, Syracuse University, New York, NY, USA.
Paul FaulknerDepartment of Psychology, University of Roehampton, London, UK.
Brandon University · CASyracuse University · USUniversity of Agder · NOUniversity of Central Florida · USUniversity of Liverpool · GBUniversity of Regina · CAUniversity of Roehampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is emerging interest regarding the potential beneficial effects of creatine supplementation on indices of brain health and function. Creatine supplementation can increase brain creatine stores, which may help explain some of the positive effects on measures of cognition and memory, especially in aging adults or during times of metabolic stress (i.e., sleep deprivation). Furthermore, creatine has shown promise for improving health outcome measures associated with muscular dystrophy, traumatic brain injury (including concussions in children), depression, and anxiety. However, whether any sex- or age-related differences exist in regard to creatine and indices of brain health and function is relatively unknown. The purpose of this narrative review is to: (1) provide an up-to-date summary and discussion of the current body of research focusing on creatine and indices of brain health and function and (2) discuss possible sex- and age-related differences in response to creatine supplementation on brain bioenergetics, measures of brain health and function, and neurological diseases.

Indexed as

BrainCreatineAdultAgingChildCognitionDietary SupplementsHumansCreatine

Identifiers

PMID37368234
PMCPMC10721691
OpenAlexW4382181834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.