ArticleJapanese journal of radiology2023
Glymphatic system impairment in sleep disruption: diffusion tensor image analysis along the perivascular space (DTI-ALPS).
Article in Japanese journal of radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Glymphatic dysfunction across sleep disorders: a meta-analysis of DTI-ALPS studies.Frontiers in neurologyPooled it
- Modifiable Physiological Factors Associated With Human Glymphatic and Interstitial Fluid Dynamics-Related Measures: A Scoping Review.The European journal of neuroscience · 2026Article
- DTI-ALPS as a marker of glymphatic function: Review of the literature findings, methodology, and interpretation.Neuroimage. Reports · 2026Article
- Subjective sleep disturbances are associated with reduced MRI-derived perivascular-space diffusivity in multiple sclerosis.Journal of neurology · 2026Article
- Association between obstructive sleep apnea severity and glymphatic-related DTI-ALPS alterations in newly diagnosed, Drug-Naïve Alzheimer's disease.The journal of prevention of Alzheimer's disease · 2026Article
- Reduced glymphatic function in autism revealed by the diffusion tensor analysis along the perivascular space index.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- White matter microstructural alterations in obstructive sleep apnea assessed by time-dependent diffusion MRI.Japanese journal of radiology · 2026Article
- Impaired Glymphatic Function and Post-stroke Cognitive Decline after Intracerebral Hemorrhage: A Serial Neuroimaging Study.Translational stroke research · 2026Article
- Developmental Alterations in the Diffusion Tensor Imaging Analysis Along the Perivascular Space Index Suggest Possible Glymphatic-Related Mechanisms Underlying Excitation/Inhibition Imbalance and Psychosis Vulnerability in 22q11.2 Deletion Syndrome.Biological psychiatry global open science · 2026Article
- Diffusion tensor image analysis along the perivascular space may serve as a potential biomarker for differentiating glioma recurrence from pseudoprogression: a preliminary study.Quantitative imaging in medicine and surgery · 2026Article
- Assessment of glymphatic system function using DTI-ALPS in depressive disorders: a study of its correlation with clinical features and plasma GFAP levels.Quantitative imaging in medicine and surgery · 2026Article
- G-ALPS: An index for evaluating cognitive decline and aging using diffusion tensor imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Choroid plexus enlargement is associated with poor functional status in cerebral small vessel disease via reduced DTI-ALPS index: a 5T MRI study.Quantitative imaging in medicine and surgery · 2026Article
- Mapping the Brain's Glymphatic System.Biomedicines · 2026Review
- Role of glymphatic system function in cognitive dysfunction among patients with bipolar disorder.The international journal of neuropsychopharmacology · 2026Article
- Alterations in the Cerebral Perivascular Space Network as a Potential Central Mechanism in Overactive Bladder: A Neuroimaging-Clinical Association Study.European urology open science · 2026Article
- Aerospace stressors and brain health in military aviators: a glymphatic-neurovascular framework.Frontiers in physiology · 2026Review
- Vicious cycle: the bidirectional relationship and pathophysiological mechanisms of tinnitus and sleep disturbance.Frontiers in neurology · 2026Review
- Impaired glymphatic function in relation to cumulative blood glucose exposure: A population-based cohort study.IBRO neuroscience reports · 2025Article
- MR Imaging Indices for Brain Interstitial Fluid Dynamics and the Effects of Orexin Antagonists on Sleep.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
Corrections and comments
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Authors and funding
21 authors.
Funding
Abstract
purposeThis study aimed to evaluate the relationship between sleep quality as assessed using the Pittsburgh Sleep Quality Index (PSQI) and the index of diffusivity along the perivascular space (ALPS index), a possible indirect indicator of glymphatic system activity. MATERIALS AND
methodsThis study included the diffusion magnetic resonance imaging (MRI) data of 317 people with sleep disruption and 515 healthy controls (HCs) from the Human Connectome Project (WU-MINN HCP 1200). The ALPS index was calculated automatically based on diffusion tensor image analysis (DTI)-ALPS of diffusion MRI. The ALPS index of the sleep disruption and HC groups was compared using general linear model (GLM) analysis with covariates, such as age, sex, level of education, and intracranial volume. In addition, to confirm the relationship between sleep quality and the ALPS index in the sleep disruption group as well as evaluate the effect of each PSQI component on the ALPS index, correlation analyses between the ALPS indices and PSQI scores of all the components and between the ALPS index and each PSQI component was performed using GLM analysis with the abovementioned covariates, respectively.
resultsThe ALPS index was significantly lower in the sleep disruption group than in the HC group (p = 0.001). Moreover, the ALPS indices showed significant negative correlations with the PSQI scores of all the components (false discovery rate [FDR]-corrected p < 0.001). Two significant negative correlations were also found between the ALPS index and PSQI component 2 (sleep latency, FDR-corrected p < 0.001) and 6 (the use of sleep medication, FDR-corrected p < 0.001).
conclusionOur findings suggest that glymphatic system impairment contributes to sleep disruption in young adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.