Evidence map›Paper›PMID 37368082›Full record

ArticleEuropean child & adolescent psychiatry2024

ADHD-related sex differences in emotional symptoms across development.

Alyssa C De Ronda, Laura Rice, Yi Zhao, Keri S Rosch, Stewart H Mostofsky, Karen E Seymour

Abstract read
In one paragraph

Article in European child & adolescent psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alyssa C De RondaCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, 716 North Broadway, Baltimore, MD, 21205, USA.
Laura RiceCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, 716 North Broadway, Baltimore, MD, 21205, USA.
Yi ZhaoDepartment of Biostatistics, Indiana University School of Medicine, 410 West 10th Street, Indianapolis, IN, 46202, USA.
Keri S RoschCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, 716 North Broadway, Baltimore, MD, 21205, USA.
Stewart H MostofskyCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, 716 North Broadway, Baltimore, MD, 21205, USA.
Karen E SeymourCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, 716 North Broadway, Baltimore, MD, 21205, USA. karen.seymour@nih.gov.ORCID https://orcid.org/0000-0003-2861-1367

Funding

Neurology of Deficient Response Control in ADHDR01MH085328 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MOSTOFSKY, STEWART H · 2009 to 2019
$7.3M
Anomalous Motor Physiology In ADHDR01MH078160 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MOSTOFSKY, STEWART H · 2006 to 2024
$5.8M
Neurobehavioral Correlates of Frustration in Children with ADHDK23MH107734 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SEYMOUR, KAREN E · 2015 to 2019
$815k
Delay Discounting in Children with ADHD: Neuroimaging and Behavioral CorrelatesK23MH101322 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI ROSCH, KERI SHIELS · 2013 to 2017
$735k
Examination of developmental trajectories of cognitive, motor and emotional control in relation to sex differences in psychopathologyR03MH119457 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI ROSCH, KERI SHIELS · 2020 to 2021
$162k
Brain and Behavior Research Foundation NARSAD Young Investigator's AwardNational Institutes of Health, United States K23MH101322National Institutes of Health, United States K23MH107734National Institutes of Health, United States R01MH078160NIMH NIH HHS K23 MH101322NIMH NIH HHS K23 MH107734NIMH NIH HHS R01 MH078160NIMH NIH HHS R01 MH085328NIMH NIH HHS R03 MH119457
6 · The paper itself

Abstract

To investigate developmental changes in emotion dysregulation (ED) and associated symptoms of emotional lability, irritability, anxiety, and depression, among girls and boys with and without ADHD from childhood through adolescence. Data were collected from a sample of 8-18-year-old children with (n = 264; 76 girls) and without (n = 153; 56 girls) ADHD, with multiple time-points from a subsample of participants (n = 121). Parents and youth completed rating scales assessing child ED, emotional lability, irritability, anxiety, and depression. Mixed effects models were employed to examine effects and interactions of diagnosis, sex [biological sex assigned at birth], age among boys and girls with and without ADHD. Mixed effects analyses showed sexually dimorphic developmental patterns between boys and girls, such that boys with ADHD showed a greater reduction in ED, irritability, and anxiety with age compared to girls with ADHD, whose symptom levels remained elevated relative to TD girls. Depressive symptoms were persistently elevated among girls with ADHD compared to boys with ADHD, whose symptoms decreased with age, relative to same-sex TD peers. While both boys and girls with ADHD showed higher levels of ED during childhood (compared to their sex-matched TD peers), mixed effects analyses revealed substantial sexually dimorphic patterns of emotional symptom change during adolescence: Boys with ADHD showed robust improvements in emotional symptoms from childhood to adolescence while girls with ADHD continued to show high and/or increased levels of ED, emotional lability, irritability, anxiety and depression.

Indexed as

Attention Deficit Disorder with HyperactivityDepressionAdolescentAffective SymptomsAnxietyChildEmotionsFemaleHumansMalePsychiatric Status Rating ScalesSex CharacteristicsSex FactorsAttention-deficit/hyperactivity disorder (ADHD)ComorbidityDevelopmental patternsEmotion regulationIrritability

Identifiers

PMID37368082
PMCPMC10986680

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.