Evidence map›Paper›PMID 37367904›Full record

ArticleMetabolites2023

Dietary Inflammatory and Insulinemic Potentials, Plasma Metabolome and Risk of Colorectal Cancer.

Dong Hoon Lee, Qi Jin, Ni Shi, Fenglei Wang, Alaina M Bever, Jun Li, Liming Liang, Frank B Hu, Mingyang Song, Oana A Zeleznik and 11 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03364582 (Dietary Patterns, Metabolomics and Colorectal Cancer Risk and Mortality in the Nurses' Health Study and Health Professionals Follow-Up Study), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03364582 completednot on this map

Dietary Patterns, Metabolomics and Colorectal Cancer Risk and Mortality in the Nurses' Health Study and Health Professionals Follow-Up Study

TypeobservationalSponsorOhio State University Comprehensive Cancer CenterRan2016 to 2022Enrolled173,230ConditionsColorectal Cancer, MortalityArmsObserved dietary pattern
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 2 countries.

Dong Hoon LeeDepartment of Sport Industry Studies, Yonsei University, Seoul 03722, Republic of Korea.
Qi JinDepartment of Exercise and Nutrition Sciences, Moyes College of Education, Weber State University, Ogden, UT 84408, USA.ORCID 0000-0002-3638-8006
Ni ShiComprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
Fenglei WangDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Alaina M BeverDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Jun LiDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Liming LiangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Frank B HuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Mingyang SongDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Oana A ZeleznikChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-8705-1163
Xuehong ZhangChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Amit JoshiClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.
Kana WuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Justin Y JeonDepartment of Sport Industry Studies, Yonsei University, Seoul 03722, Republic of Korea.ORCID 0000-0001-7978-4271
Jeffrey A MeyerhardtDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Andrew T ChanChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
A Heather EliassenDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-3961-6609
Clary B ClishDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0001-8259-9245
Steven K ClintonComprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
Edward L GiovannucciDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Fred K TabungDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0001-8193-7150
Harvard University · USBrigham and Women's Hospital · USThe Ohio State University · USBroad Institute · USWeber State University · USYonsei University · KR

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Pro-inflammatory and Hyper-insulinemic Dietary Patterns and Colorectal Cancer Risk: Role of the MetabolomeR00CA207736 · NCI · OHIO STATE UNIVERSITY · PI TABUNG, FRED KINYUY · 2018 to 2020
$747k
Chronic Inflammation and Type 2 Diabetes: A Multi-omics ApproachR00DK122128 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI LI, JUN · 2022 to 2024
$723k
Metabolomic signatures of inflammation and metabolic health in relation to colorectal cancer riskF30CA265012 · NCI · HARVARD MEDICAL SCHOOL · PI BEVER, ALAINA · 2022 to 2025
$187k
NCI NIH HHS F30 CA265012NCI NIH HHS P01 CA087969NCI NIH HHS R00 CA207736NCI NIH HHS R01 CA050385NCI NIH HHS U01 CA167552NCI NIH HHS U01 CA176726NCI NIH HHS UM1 CA186107NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R00 DK122128NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273NIH HHS P01 CA87969NIH HHS R00 CA207736NIH HHS R01 CA50385NIH HHS U01 CA167552NIH HHS U01 CA176726NIH HHS UM1 CA186107
6 · The paper itself

Abstract

The inflammatory and insulinemic potentials of diets have been associated with colorectal cancer risk. However, it is unknown whether the plasma metabolite profiles related to inflammatory diets, or to insulinemic diets, underlie this association. The aim of this study was to evaluate the association between metabolomic profile scores related to the food-based empirical dietary inflammatory patterns (EDIP), the empirical dietary index for hyperinsulinemia (EDIH), and plasma inflammation (CRP, IL-6, TNFα-R2, adiponectin) and insulin (C-peptide) biomarkers, and colorectal cancer risk. Elastic net regression was used to derive three metabolomic profile scores for each dietary pattern among 6840 participants from the Nurses' Health Study and Health Professionals Follow-up Study, and associations with CRC risk were examined using multivariable-adjusted logistic regression, in a case-control study of 524 matched pairs nested in both cohorts. Among 186 known metabolites, 27 were significantly associated with both the EDIP and inflammatory biomarkers, and 21 were significantly associated with both the EDIH and C-peptide. In men, odds ratios (ORs) of colorectal cancer, per 1 standard deviation (SD) increment in metabolomic score, were 1.91 (1.31-2.78) for the common EDIP and inflammatory-biomarker metabolome, 1.12 (0.78-1.60) for EDIP-only metabolome, and 1.65 (1.16-2.36) for the inflammatory-biomarkers-only metabolome. However, no association was found for EDIH-only, C-peptide-only, and the common metabolomic signatures in men. Moreover, the metabolomic signatures were not associated with colorectal cancer risk among women. Metabolomic profiles reflecting pro-inflammatory diets and inflammation biomarkers were associated with colorectal cancer risk in men, while no association was found in women. Larger studies are needed to confirm our findings.

Indexed as

colorectal cancerC-peptideempirical dietary index for hyperinsulinemiaempirical dietary inflammatory patterninflammation biomarkersplasma metabolomic profiles

Identifiers

PMID37367904
PMCPMC10304271
OpenAlexW4380484284

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.