Evidence map›Paper›PMID 37367824›Full record

ArticleBiomaterials science2023

Differentiation state and culture conditions impact neural stem/progenitor cell-derived extracellular vesicle bioactivity.

Dipankar Dutta, Nicholas H Pirolli, Daniel Levy, Jeffrey Tsao, Nicholas Seecharan, Zihui Wang, Xiang Xu, Xiaofeng Jia, Steven M Jay

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Dipankar DuttaFischell Department of Bioengineering, University of Maryland, College Park, MD, USA. smjay@umd.edu.
Nicholas H PirolliFischell Department of Bioengineering, University of Maryland, College Park, MD, USA. smjay@umd.edu.
Daniel LevyFischell Department of Bioengineering, University of Maryland, College Park, MD, USA. smjay@umd.edu.
Jeffrey TsaoFischell Department of Bioengineering, University of Maryland, College Park, MD, USA. smjay@umd.edu.
Nicholas SeecharanFischell Department of Bioengineering, University of Maryland, College Park, MD, USA. smjay@umd.edu.
Zihui WangDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA. xjia@som.umaryland.edu.
Xiang XuDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA. xjia@som.umaryland.edu.
Xiaofeng JiaDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA. xjia@som.umaryland.edu.ORCID http://orcid.org/0000-0003-1445-8525
Steven M JayFischell Department of Bioengineering, University of Maryland, College Park, MD, USA. smjay@umd.edu.ORCID http://orcid.org/0000-0002-3827-5988
University of Maryland, College Park · USUniversity of Maryland, Baltimore · US

Funding

Dementia Following Spinal Cord Injury: Mechanism and Therapeutic TargetingRF1NS110637 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI JAY, STEVEN MICHAEL, WU, JUNFANG · 2019 to 2019
$2.8M
Stem Cell Surface Modification to Promote Nerve RegenerationR01NS117102 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI Xiaofeng Jia · 2021 to 2026
$2.0M
Controlling Exosome Noncoding RNA Cargo for Enhanced Wound HealingR01HL141611 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI JAY, STEVEN MICHAEL · 2018 to 2022
$1.9M
NHLBI NIH HHS R01 HL141611NINDS NIH HHS R01 NS117102NINDS NIH HHS RF1 NS110637
6 · The paper itself

Abstract

Extracellular vesicles (EVs) derived from neural progenitor/stem cells (NPSCs) have shown promising efficacy in a variety of preclinical models. However, NPSCs lack critical neuroregenerative functionality such as myelinating capacity. Further, culture conditions used in NPSC EV production lack standardization, limiting reproducibility challenging and potentially potency of the overall approach

Indexed as

Extracellular VesiclesNeural Stem CellsAnimalsCell DifferentiationNerve Growth FactorRatsRats, Sprague-DawleyReproducibility of ResultsNerve Growth Factor

Identifiers

PMID37367824
PMCPMC10529403
OpenAlexW4382181704

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.