Evidence map›Paper›PMID 37367692›Full record

ArticleMarine drugs2023

Expanding the Utility of Bioinformatic Data for the Full Stereostructural Assignments of Marinolides A and B, 24- and 26-Membered Macrolactones Produced by a Chemically Exceptional Marine-Derived Bacterium.

Min Cheol Kim, Jaclyn M Winter, Reiko Cullum, Alexander J Smith, William Fenical

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Min Cheol KimCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, Skaggs School of Pharmacy and Pharmaceutical Sciences, Moores Comprehensive Cancer Center, University of California, La Jolla, San Diego, CA 92093, USA.ORCID 0000-0002-9861-6131
Jaclyn M WinterDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0001-6273-5377
Reiko CullumCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, Skaggs School of Pharmacy and Pharmaceutical Sciences, Moores Comprehensive Cancer Center, University of California, La Jolla, San Diego, CA 92093, USA.ORCID 0000-0003-0884-1640
Alexander J SmithCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, Skaggs School of Pharmacy and Pharmaceutical Sciences, Moores Comprehensive Cancer Center, University of California, La Jolla, San Diego, CA 92093, USA.ORCID 0000-0002-7987-1460
William FenicalCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, Skaggs School of Pharmacy and Pharmaceutical Sciences, Moores Comprehensive Cancer Center, University of California, La Jolla, San Diego, CA 92093, USA.

Funding

Antitumor-Antibiotics from Marine MicroorganismsR37CA044848 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FENICAL, WILLIAM · 2004 to 2013
$3.9M
Genomics-Assisted Antibiotic Discovery from Unprecedented Microbes of the Great Salt LakeR01AI155694 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI WINTER, JACLYN MARIE · 2021 to 2025
$3.1M
ANTITUMOR ANTIBIOTICS FROM MARINE ORGANISMSR01CA044848 · NCI · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI FENICAL, WILLIAM · 1987 to 2003
$1.2M
NCI NIH HHS CA044848NCI NIH HHS R01 CA044848NCI NIH HHS R37 CA044848NIAID NIH HHS R01 AI155694NIH HHS 1R01AI155694
6 · The paper itself

Abstract

Marinolides A and B, two new 24- and 26-membered bacterial macrolactones, were isolated from the marine-derived actinobacterium AJS-327 and their stereostructures initially assigned by bioinformatic data analysis. Macrolactones typically possess complex stereochemistry, the assignments of which have been one of the most difficult undertakings in natural products chemistry, and in most cases, the use of X-ray diffraction methods and total synthesis have been the major methods of assigning their absolute configurations. More recently, however, it has become apparent that the integration of bioinformatic data is growing in utility to assign absolute configurations. Genome mining and bioinformatic analysis identified the 97 kb

Indexed as

Biological ProductsPolyketide SynthasesBacteriaComputational BiologyMacrolidesBiological ProductsMacrolidesPolyketide Synthasesbioinformaticsgenome miningmacrolactonemodular type I polyketide synthasenatural product structure elucidation

Identifiers

PMID37367692
PMCPMC10301374

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.