Evidence map›Paper›PMID 37367681›Full record

ArticleMarine drugs2023

Synthesis and Biological Activity of Novel α-Conotoxins Derived from Endemic Polynesian Cone Snails.

Yazid Mohamed Souf, Gonxhe Lokaj, Veeresh Kuruva, Yakop Saed, Delphine Raviglione, Ashraf Brik, Annette Nicke, Nicolas Inguimbert, Sébastien Dutertre

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. An N-Terminally Elongated Peptide From Conus rolani Defines a New Class of Ribbon α-Conotoxins Targeting Muscle nAChRs.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Yazid Mohamed SoufCRIOBE, UAR CNRS-EPHE-UPVD 3278, Université de Perpignan Via Domitia, 58 Avenue Paul Alduy, 66860 Perpignan, France.ORCID 0000-0002-1717-9137
Gonxhe LokajFaculty of Medicine, Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Nußbaumstraße 26, 80336 Munich, Germany.
Veeresh KuruvaSchulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 3200008, Israel.
Yakop SaedSchulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 3200008, Israel.
Delphine RaviglioneCRIOBE, UAR CNRS-EPHE-UPVD 3278, Université de Perpignan Via Domitia, 58 Avenue Paul Alduy, 66860 Perpignan, France.ORCID 0000-0002-8269-5947
Ashraf BrikSchulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 3200008, Israel.ORCID 0000-0001-8745-2250
Annette NickeFaculty of Medicine, Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Nußbaumstraße 26, 80336 Munich, Germany.ORCID 0000-0001-6798-505X
Nicolas InguimbertCRIOBE, UAR CNRS-EPHE-UPVD 3278, Université de Perpignan Via Domitia, 58 Avenue Paul Alduy, 66860 Perpignan, France.ORCID 0000-0002-0309-9048
Sébastien DutertreIBMM, Université Montpellier, CNRS, ENSCM, 34093 Montpellier, France.ORCID 0000-0002-2945-1484
Centre National de la Recherche Scientifique · FRTechnion – Israel Institute of Technology · ILLudwig-Maximilians-Universität München · DEÉcole Nationale Supérieure de Chimie de Montpellier · FR

Funding

Agence Nationale de la Recherche ANR-20-BFOC-0005Deutsche Forschungsgemeinschaft GRK2338, P01
6 · The paper itself

Abstract

α-Conotoxins are well-known probes for the characterization of the various subtypes of nicotinic acetylcholine receptors (nAChRs). Identifying new α-conotoxins with different pharmacological profiles can provide further insights into the physiological or pathological roles of the numerous nAChR isoforms found at the neuromuscular junction, the central and peripheral nervous systems, and other cells such as immune cells. This study focuses on the synthesis and characterization of two novel α-conotoxins obtained from two species endemic to the Marquesas Islands, namely

Indexed as

ConotoxinsConus SnailReceptors, NicotinicAnimalsNicotinic AntagonistsPolynesiaRatsSnailsConotoxinsNicotinic AntagonistsReceptors, Nicotinicconotoxinnicotinic acetylcholine receptorspeptide synthesistwo-electrode voltage clamp

Identifiers

PMID37367681
PMCPMC10301793
OpenAlexW4380371746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.