Evidence map›Paper›PMID 37367419›Full record

ArticleJournal of cardiovascular development and disease2023

Characterization of Green Fluorescent Protein in Heart Valves of a Transgenic Swine Model for Partial Heart Transplant Research.

Katherine Bishara, Jennie H Kwon, Morgan A Hill, Kristi L Helke, Russell A Norris, Kristin Whitworth, Randall S Prather, Taufiek Konrad Rajab

Open access · goldAbstract read
In one paragraph

Article in Journal of cardiovascular development and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Baseline Characterization of Swine Leukocyte Antigen Diversity in GFP-Expressing Domestic Swine.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Katherine BisharaDepartment of Surgery, Medical University of South Carolina, Charleston, SC 29501, USA.ORCID 0000-0002-9785-9836
Jennie H KwonDepartment of Surgery, Medical University of South Carolina, Charleston, SC 29501, USA.
Morgan A HillDepartment of Surgery, Medical University of South Carolina, Charleston, SC 29501, USA.
Kristi L HelkeDepartment of Comparative Medicine, Medical University of South Carolina, Charleston, SC 29501, USA.
Russell A NorrisDepartment of Regenerative Medicine, Medical University of South Carolina, Charleston, SC 29501, USA.
Kristin WhitworthNational Swine Resource and Research Center, University of Missouri, Columbia, MO 65211, USA.
Randall S PratherNational Swine Resource and Research Center, University of Missouri, Columbia, MO 65211, USA.ORCID 0000-0002-6012-4035
Taufiek Konrad RajabDepartment of Surgery, Medical University of South Carolina, Charleston, SC 29501, USA.
Medical University of South Carolina · USUniversity of Missouri · US

Funding

Resource Core for National Swine Resource and Research Center (NSRRC) Years 21-25U42OD011140 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI RANDALL S PRATHER · 2012 to 2026
$26.7M
Cilia and Valvular Heart DiseaseR01HL131546 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI NORRIS, RUSSELL · 2016 to 2025
$4.4M
Evaluation of growth potential of ice-free vitrified heart valves in a pediatric porcine model.R41HL169059 · NHLBI · TISSUE TESTING TECHNOLOGIES, LLC · PI RAJAB, TAUFIEK KONRAD · 2023 to 2023
$611k
NHLBI NIH HHS R01 HL131546NHLBI NIH HHS R41 HL169059NIH HHS U42 OD011140
6 · The paper itself

Abstract

A transgenic strain of pigs was created to express green fluorescent protein (GFP) ubiquitously using a pCAGG promoter. Here, we characterize GFP expression in the semilunar valves and great arteries of GFP-transgenic (GFP-Tg) pigs. Immunofluorescence was performed to visualize and quantify GFP expression and colocalization with nuclear staining. GFP expression was confirmed in both the semilunar valves and great arteries of GFP-Tg pigs compared to wild-type tissues (aorta,

Indexed as

heart transplantimmunohistochemistryswine modeltransgenic

Identifiers

PMID37367419
PMCPMC10299052
OpenAlexW4380324428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.