Gelation and Orientation Dynamics Induced by Contact of Protein Solution with Transglutaminase Solution.

Kasumi Kakinoki, Ryuta Kurasawa, Yasuyuki Maki, Toshiaki Dobashi, Takao Yamamoto

Abstract read

In one paragraph

Article in Gels (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kasumi KakinokiDivision of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu 376-8515, Japan.

Ryuta KurasawaDivision of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu 376-8515, Japan.

Yasuyuki MakiDepartment of Chemistry, Faculty of Science, Kyushu University, Fukuoka 819-0395, Japan.ORCID 0000-0002-3157-4344

Toshiaki DobashiDivision of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu 376-8515, Japan.ORCID 0000-0001-9739-228X

Takao YamamotoDivision of Pure and Applied Science, Graduate School of Science and Technology, Gunma University, Kiryu 376-8515, Japan.ORCID 0000-0001-8094-1078

Funding

Japan Society for the Promotion of Science JP24350115, JP15K05241 and JP18K03556

6 · The paper itself

Abstract

Gel growth induced by contact of polymer solutions with crosslinker solutions yields an emerging class of anisotropic materials with many potential applications. Here, we report the case of a study on the dynamics in forming anisotropic gels using this approach with an enzyme as a trigger of gelation and gelatin as the polymer. Unlike the previously studied cases of gelation, the isotropic gelation was followed by gel polymer orientation after a lag time. The isotropic gelation dynamics did not depend on concentrations of the polymer turning into gel and of the enzyme inducing gelation, whereas, for the anisotropic gelation, the square of the gel thickness was a linear function of the elapsed time, and the slope increased with polymer concentration. The gelation dynamics of the present system was explained by a combination of diffusion-limited gelation followed by free-energy-limited orientation of polymer molecules.

Indexed as

anisotropic geldiffusion-limited processenzymefree-energy-limited processgel growth dynamicsliquid–liquid contactprotein

Identifiers

PMID37367148

DOI10.3390/gels9060478

PMCPMC10297716

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