ArticleBiosensors2023
BPA Endocrine Disruptor Detection at the Cutting Edge: FPIA and ELISA Immunoassays.
Article in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- A molecularly imprinted electrochemical sensor for detection of bisphenol A based on dendritic Pt-Pd bimetallic nanoparticles and g-CMikrochimica acta · 2026Article
- DNA Damage and Bisphenol Levels in Chronic Kidney Disease Patients Undergoing Hemodialysis.Journal of xenobiotics · 2025Article
- Disrupting Defenses: Effects of Bisphenol A and Its Analogs on Human Antibody Production In Vitro.Life (Basel, Switzerland) · 2025Article
- Sensitive and rapid detection of bisphenol A using signal amplification nanoparticles loaded with anti-bisphenol A monoclonal antibody.Food chemistry: X · 2024Article
- Comparison of Conjugates Obtained Using DMSO and DMF as Solvents in the Production of Polyclonal Antibodies and ELISA Development: A Case Study on Bisphenol A.Antibodies (Basel, Switzerland) · 2024Article
- Molecularly imprinted photopolymers combined with smartphone-based optical sensing for selective detection of bisphenol A in foods.Analytical and bioanalytical chemistry · 2024Article
- Detection of Dibutyl Phthalate in Surface Water by Fluorescence Polarization Immunoassay.Biosensors · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
BPA is a chemical commonly used in the production of polymer-based materials that can have detrimental effects on the thyroid gland and impact human reproductive health. Various expensive methods, such as liquid and gas chromatography, have been suggested for detecting BPA. The fluorescence polarization immunoassay (FPIA) is an inexpensive and efficient homogeneous mix-and-read method that allows for high-throughput screening. FPIA offers high specificity and sensitivity and can be carried out in a single phase within a timeframe of 20-30 min. In this study, new tracer molecules were designed that linked the fluorescein fluorophore with and without a spacer to the bisphenol A moiety. To assess the influence of the C6 spacer on the sensitivity of an assay based on the respective antibody, hapten-protein conjugates were synthesized and assessed for performance in an ELISA setup, and this resulted in a highly sensitive assay with a detection limit of 0.05 g/L. The lowest limit of detection was reached by employing the spacer derivate in the FPIA and was 1.0 μg/L, working range from 2 to 155 μg/L. The validation of the methods was conducted using actual samples compared to LC-MS/MS, which served as the reference method. The FPIA and ELISA both demonstrated satisfactory concordance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.