Evidence map›Paper›PMID 37366825›Full record

ArticleBiomimetics (Basel, Switzerland)2023

A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study.

Thomas Breslin, Jason Paino, Marie Wegner, Elette Engels, Stefan Fiedler, Helen Forrester, Hannes Rennau, John Bustillo, Matthew Cameron, Daniel Häusermann and 5 more

Abstract read
In one paragraph

Article in Biomimetics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Thomas BreslinDepartment of Oncology, Clinical Sciences, Lund University, 22185 Lund, Sweden.
Jason PainoCentre of Medical Radiation Physics, University of Wollongong, Wollongong 2522, Australia.ORCID 0000-0002-3648-7880
Marie WegnerInstitute of Product Development and Mechanical Engineering Design, Hamburg University of Technology, 21073 Hamburg, Germany.ORCID 0000-0001-8616-859X
Elette EngelsCentre of Medical Radiation Physics, University of Wollongong, Wollongong 2522, Australia.ORCID 0000-0003-4704-2104
Stefan FiedlerEuropean Molecular Biology Laboratory (EMBL), Hamburg Outstation, 22607 Hamburg, Germany.ORCID 0000-0002-3623-3311
Helen ForresterSchool of Science, Royal Melbourne Institute of Technology (RMIT) University, Melbourne 3001, Australia.
Hannes RennauDepartment of Radiooncology, Rostock University Medical Center, 18059 Rostock, Germany.
John BustilloCentre of Medical Radiation Physics, University of Wollongong, Wollongong 2522, Australia.
Matthew CameronAustralian Synchrotron/ANSTO, Clayton 3168, Australia.
Daniel HäusermannAustralian Synchrotron/ANSTO, Clayton 3168, Australia.
Christopher HallAustralian Synchrotron/ANSTO, Clayton 3168, Australia.
Dieter KrauseInstitute of Product Development and Mechanical Engineering Design, Hamburg University of Technology, 21073 Hamburg, Germany.ORCID 0000-0002-1253-1699
Guido HildebrandtDepartment of Radiooncology, Rostock University Medical Center, 18059 Rostock, Germany.
Michael LerchCentre of Medical Radiation Physics, University of Wollongong, Wollongong 2522, Australia.
Elisabeth SchültkeDepartment of Radiooncology, Rostock University Medical Center, 18059 Rostock, Germany.

Funding

Deutsche Forschungsgemeinschaft 2589/7German Academic Exchange Service PPP 57650979Swedish Foundation for International Cooperation in Research and Higher Education 0
6 · The paper itself

Abstract

The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.

Indexed as

anthropomorphic phantomCT scandosimetryexperimental radiotherapymicrobeam radiotherapy (MRT)therapy planningtissue-equivalent materials

Identifiers

PMID37366825
PMCPMC10296262

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.