ReviewDentistry journal2023
Do Systemic Diseases and Medications Influence Dental Implant Osseointegration and Dental Implant Health? An Umbrella Review.
Review in Dentistry journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Dental implant outcomes in patients with diabetes mellitus: a systematic review.BMC oral health · 2026Pooled it
- Implant Survival in Patient Populations With a Mean Age of 65-75 Years Compared to Older Cohorts: A Systematic Review and Meta-Analysis.Clinical oral implants research · 2025Pooled it
- Low intensity pulsed ultrasound versus low-level laser therapy on peri-implant marginal bone preservation and soft tissue healing following dental implant surgery: a randomized controlled trial.Head & face medicine · 2025Trial
- The Impact of Cancer Treatment On Oral Structures and the Facial Part of the Skull - Implications for Prosthetic Treatment and Oncological Risk.Current oncology reports · 2026Review
- Perioperative loxoprofen sodium is associated with lower pain and anxiety levels in dental implant surgery: a cohort study in China.Clinical oral investigations · 2026Article
- Investigation of the long-term prognosis (3-13 Years) of full mouth implant prosthetics combining zygomatic implants based on the all-on-four concept.International journal of implant dentistry · 2026Article
- Submental abscess following anterior mandibular implantation: A case report and comprehensive literature review.Journal of advanced periodontology & implant dentistry · 2026Article
- Dental implant rehabilitation in a patient with primary hyperoxaluria type 1: a 14-month case report.BMC oral health · 2026Article
- Technical and biological complications of implant-supported fixed complete dentures: a retrospective cohort study with up to 17 years of follow-up.International journal of implant dentistry · 2026Article
- Review
- Current treatment concepts in implantology in oral and maxillofacial surgery in Germany.International journal of implant dentistry · 2026Article
- The Effect of Titanium Dioxide Nanotubes and Graphene Compounds on the Proliferation and Osteogenic Differentiation of Rat BMSCs.Journal of functional biomaterials · 2025Article
- A Multicenter Study of Factors Related to Early Implant Failures-Part 2: Patient Factors.Clinical implant dentistry and related research · 2025Article
- Impact of continued antithrombotic use on bleeding risk in oral surgery- a retrospectively study in a population patients treated in a Korean university hospital.Journal of dental sciences · 2025Article
- Unveiling Drug-Drug Interactions in Dental Patients: A Retrospective Real-World Study.Dentistry journal · 2025Article
- Comparison Between Micro- and Micro-Nano Surface Texturization in the Initial Osseointegration Process: An Experimental In Vitro and In Vivo Preclinical Study.Bioengineering (Basel, Switzerland) · 2025Article
- Influencing factors and survival rates in immediate vs. delayed dental implant placement: a six-year retrospective analysis.Frontiers in dental medicine · 2025Article
- Correlation between marginal bone loss around dental implants and various systemic diseases: a cross-sectional study.International journal of implant dentistry · 2024Article
- Review
- Peri-Implantitis-Associated Microbiota before and after Peri-Implantitis Treatment, the Biofilm "Competitive Balancing" Effect: A Systematic Review of Randomized Controlled Trials.Microorganisms · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this umbrella review is to evaluate what are the most common medications and systemic diseases that can affect bone-implant integration, the success rate and survival rate of dental implants, peri-implant tissue health, and implant loss. Systematic reviews, with meta-analysis or not, about how systemic diseases and medications influence dental implant osseointegration, survival rate, success rate, and peri-implant diseases, published only in the English language, are electronically searched across the most important scientific databases. The present umbrella review includes eight systematic reviews, and osteoporosis and diabetes are the most investigated pathologies. Systemic diseases, such as neurologic disorders, HIV, hypothyroidism, cardiovascular diseases, and drugs, such as beta blockers, anti-hypertensives, or diuretics do not show a decreased rate of implant osseointegration. It seems that drugs, such as proton-pump inhibitors (PPIs) or serotonin reuptake inhibitors (SSRIs), negatively affect implant osseointegration. Few studies compare the effects of drugs and systemic diseases on the parameters considered in this overview. It is important to underline how the results of this review need to be validated with subsequent and more reviews.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.