Evidence map›Paper›PMID 37366543›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2023

Hepatocyte-specific loss of LAP2α protects against diet-induced hepatic steatosis, steatohepatitis, and fibrosis in male mice.

Kapil K Upadhyay, Eun-Young K Choi, Roland Foisner, M Bishr Omary, Graham F Brady

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Kapil K UpadhyayDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0002-0000-5085
Eun-Young K ChoiDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, United States.
Roland FoisnerMax Perutz Labs, Medical University of Vienna, Vienna Biocenter Campus, Vienna, Austria.
M Bishr OmaryRobert Wood Johnson Medical School and the Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey, United States.
Graham F BradyDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0002-8376-5871
University of Michigan · USMax Perutz Labs · ATRutgers, The State University of New Jersey · US

Funding

Michigan Mouse Metabolic Phenotyping CenterU2CDK110768 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELIAS, CAROL FUZETI · 2016 to 2021
$6.2M
Mechanism of Proteotoxicity and Experimental Therapeutic Approaches in PorphyriaR01DK116548 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bishr Omary · 2017 to 2026
$3.8M
Nuclear lamins and the hepatocyte nuclear envelope in nonalcoholic fatty liver diseaseK08DK120948 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRADY, GRAHAM F. · 2020 to 2024
$839k
Austrian Science Fund FWF W 1261NIDDK NIH HHS K08 DK120948NIDDK NIH HHS R01 DK116548NIDDK NIH HHS U2C DK110768
6 · The paper itself

Abstract

There is increasing evidence for the importance of the nuclear envelope in lipid metabolism, nonalcoholic fatty liver disease (NAFLD), and nonalcoholic steatohepatitis (NASH). Human mutations in

Indexed as

Non-alcoholic Fatty Liver DiseaseAnimalsDiet, High-FatDisease Models, AnimalDNA-Binding ProteinsHepatocytesHumansLaminsLiverLiver CirrhosisMaleMembrane ProteinsMiceMice, Inbred C57BLDNA-Binding Proteinslamina-associated polypeptide 2LaminsMembrane Proteinslamin A/CLAP2αnuclear envelopesteatohepatitis

Identifiers

PMID37366543
PMCPMC10396226
OpenAlexW4382182914

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.