Evidence map›Paper›PMID 37366529›Full record

ArticleHeliyon2023

Cardiac evaluation of hospitalized children with 2019 coronavirus (COVID-19) infection at a single large quaternary center.

Qimin Ng, Yue-Hin Loke, Karen L Smith, Roberta L DeBiasi, Charles I Berul, Matthew P Sharron, David Wessel, James E Bost, Robert W Lowndes, Emily Ansusinha and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qimin NgPediatric Residency Program, Medstar Georgetown University Hospital, Washington, DC, USA.
Yue-Hin LokeDivision of Cardiology, Children's National Hospital, Washington, DC, USA.
Karen L SmithDepartment of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
Roberta L DeBiasiDepartment of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
Charles I BerulDivision of Cardiology, Children's National Hospital, Washington, DC, USA.
Matthew P SharronDepartment of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
David WesselDepartment of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
James E BostDepartment of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
Robert W LowndesDivision of Cardiology, Children's National Hospital, Washington, DC, USA.
Emily AnsusinhaDivision of Infectious Diseases, Children's National Hospital, Washington, DC, USA.
Kristine MehrtensDivision of Cardiology, Children's National Hospital, Washington, DC, USA.
John SchultzDivision of Ambulatory Services, Children's National Hospital, Washington, DC, USA.
Ashraf S HarahshehDivision of Cardiology, Children's National Hospital, Washington, DC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cardiac complications of serious SARS-CoV-2 infections, especially Multisystem Inflammatory Syndrome of Children (MIS-C) are well described, however current studies have not considered pediatric patients hospitalized with no cardiac concerns. We established a protocol for cardiac evaluation of all admitted COVID-19 patients three weeks post-discharge, irrespective of cardiac concerns. We assessed cardiovascular outcomes and hypothesized that patients with absent cardiac concerns are at lower risk for cardiac abnormalities. Methods: This was a retrospective study of 160 patients admitted for COVID-19 (excluding MIS-C) between March 2020 and September 2021 with subsequent echocardiogram(s) performed at our center. Patients were divided into 4 subgroups: Group 1 included patients with absent cardiac concerns, admitted to acute care (1a) and intensive care unit (ICU) (1 b). Group 2 included patients with cardiac concerns, admitted to acute care (2a) and ICU (2 b). Groups were compared based on clinical endpoints and echocardiographic measurements, including tissue Doppler imaging (TDI) assessment of diastolic function (z-score of septal Mitral E/TDI E' and lateral E/TDI E'). Chi-squared, Fisher's exact, and Kruskal-Wallis tests were used. Results: Traditional cardiac abnormalities varied significantly between the groups; with Group 2 b having the most (n = 8, 21%), but still found in Group 1a (n = 2, 3%) and Group 1 b (n = 1, 5%). No patients in Group 1 demonstrated abnormal systolic function, compared to Group 2a (n = 1, 3%) and Group 2 b (n = 3, 9%, p = 0.07). When including TDI assessment of diastolic function, the total incidence of abnormalities found on echocardiogram was increased in all groups. Conclusion: Cardiac abnormalities were found in pediatric patients admitted with COVID-19, even those without apparent cardiovascular concerns. The risk was greatest in ICU-admitted patients with cardiac concerns. The clinical significance of diastolic function assessment in these patients remains unknown. Further studies are needed to assess long-term cardiovascular sequelae of children with COVID-19, irrespective of cardiac concerns.

Indexed as

Ambulatory cardiologyCardiac abnormalitiesCoronavirus 2019COVID-19EchocardiogramInpatientMIS-CMultisystem inflammatory syndrome in childrenOutpatientPediatric cardiology

Identifiers

PMID37366529
PMCPMC10277255

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.