ArticleInternational journal of chronic obstructive pulmonary disease2023
Trajectories of Spirometric Patterns, Obstructive and PRISm, in a Population-Based Cohort in Latin America.
Article in International journal of chronic obstructive pulmonary disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07387432 (Role of Exercise in Functional Capacity of Smokers and Subsequent Development of Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 37 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Exercise in Functional Capacity of Smokers and Subsequent Development of Chronic Obstructive Pulmonary Disease
Who cites it
37 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Prevalence of preserved ratio impaired spirometry and restrictive spirometry pattern in the general population: a systematic review and multi-level meta-analysis of studies from multiple countries.Journal of global health · 2026Pooled it
- Definitions of early COPD and predictors for disease progression: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Pooled it
- GOLD Science Committee recommendations for the use of pre- and post-bronchodilator spirometry for the diagnosis of COPD.The European respiratory journal · 2025Guideline
- Association of preserved ratio impaired spirometry with mortality and cardiovascular diseases: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- Low appendicular muscle mass and the risk of COPD development in people with PRISm.ERJ open research · 2026Article
- Automated 3D chest CT muscle segmentation-derived model development and explanation in discrimination of normal, preserved ratio impaired spirometry, and COPD: a multicenter study.Insights into imaging · 2026Article
- Trajectory of preserved ratio impaired spirometry (PRISm): patterns, predictors, and potential interventions.Clinical and experimental medicine · 2026Review
- Prevalence, longitudinal trajectory, and mortality of preserved ratio impaired spirometry (PRISm) in a Thai hospital-based cohort study.Journal of thoracic disease · 2026Article
- Prevalence of PRISm and COPD and associated factors in a university medical centre spirometry unit: a cross-sectional analysis.BMJ open · 2026Article
- Methodological Aspects of Slow-Paced Breathing in Healthy Young Individuals with Optimal and Suboptimal Spirometric Indices.Life (Basel, Switzerland) · 2026Article
- Preserved Ratio Impaired Spirometry in Low- and Middle-Income Countries: An Emerging Cardiopulmonary Phenotype and Cardiovascular Risk-A Narrative Review.Life (Basel, Switzerland) · 2026Review
- Phenotyping preserved ratio impaired spirometry (PRISm) using quantitative high-resolution computed tomography imaging features.Quantitative imaging in medicine and surgery · 2026Article
- Asthma outcomes in adults with preserved ratio impaired spirometry: a cohort study.ERJ open research · 2026Article
- Prevalence and Spirometric Transitions of PRISm and Obstruction: A Population-Based Study.Respirology (Carlton, Vic.) · 2026Article
- The risk factors of future exacerbations and treatment responses among different inhalation therapies of patients with preserved ratio impaired spirometry.Journal of global health · 2026Article
- The Inflammation-Metabolism Axis in Preserved Ratio Impaired Spirometry: Pathogenic Mechanisms and Translational Implications.Journal of inflammation research · 2026Review
- Difference in Respiratory Function Between GOLD Stage 1 and Preserved Ratio Impaired Spirometry as Assessed by Impulse Oscillometry and Spirometry.International journal of chronic obstructive pulmonary disease · 2026Article
- Clinical characteristics and outcomes associated with preserved ratio impaired spirometry (PRISm) in Saudi Arabia.Frontiers in medicine · 2026Article
- Prognostic impact of pre- and post-bronchodilator airflow obstruction and post-bronchodilator reference values in a population-based study. On behalf of the PLATINO group.Respiratory research & clinical practice · 2026Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Preserved ratio impaired spirometry (PRISm) has been associated with adverse outcomes and increased transition to other spirometric categories over time. We aimed to examine its prevalence, trajectories over time, and outcomes in a population-based sample from Latin America. Methods: Data were obtained from two population-based surveys of adults from three cities in Latin America (PLATINO study), conducted on the same individuals 5-9 years after their baseline examination. We estimated the frequency of PRISm defined by FEV Results: At baseline, 2942 participants completed post-bronchodilator spirometry, and 2026 at both evaluations. The prevalence of normal spirometry was 78%, GOLD-stage 1 10.6%, GOLD 2-4 6.5%, and PRISm was: 5.0% (95% CI 4.2-5.8). PRISm was associated with less schooling, more reports of physician-diagnosis of COPD, wheezing, dyspnea, missing days at work, having ≥2 exacerbations in the previous year but without accelerated lung function decline. Mortality risk was significantly higher in PRISm (HR 1.97, 95% CI 1.2-3.3) and COPD GOLD 1-4 categories (HR 1.79, 95% CI 1.3-2.4) compared with normal spirometry. PRISm at baseline most frequently transitioned to another category at follow-up (46.5%); 26.7% to normal spirometry and 19.8% to COPD. The best predictors of transition to COPD were closeness of FEV Conclusion: PRISm, is a heterogeneous and unstable condition prone to adverse outcomes that require adequate follow-up.
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