Evidence map›Paper›PMID 37366177›Full record

ArticleACS nano2023

MoS

Mahsa Jalali, Carolina Del Real Mata, Laura Montermini, Olivia Jeanne, Imman I Hosseini, Zonglin Gu, Cristiana Spinelli, Yao Lu, Nadim Tawil, Marie Christine Guiot and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in ACS nano, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 74 citations in OpenAlex.

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  20. Machine-Learning-Aided Advanced Electrochemical Biosensors.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Mahsa JalaliDepartment of Bioengineering, McGill University, Montreal, Quebec H3A 0E9, Canada.ORCID 0000-0003-2353-3910
Carolina Del Real MataDepartment of Bioengineering, McGill University, Montreal, Quebec H3A 0E9, Canada.
Laura MonterminiResearch Institute of the McGill University Health Centre (RIMUHC), Montreal, Quebec H4A 3J1, Canada.
Olivia JeanneDepartment of Bioengineering, McGill University, Montreal, Quebec H3A 0E9, Canada.
Imman I HosseiniDepartment of Bioengineering, McGill University, Montreal, Quebec H3A 0E9, Canada.
Zonglin GuCollege of Physical Science and Technology, Yangzhou University, Yangzhou, Jiangsu 225009, China.ORCID 0000-0001-7822-5857
Cristiana SpinelliResearch Institute of the McGill University Health Centre (RIMUHC), Montreal, Quebec H4A 3J1, Canada.
Yao LuDepartment of Bioengineering, McGill University, Montreal, Quebec H3A 0E9, Canada.
Nadim TawilResearch Institute of the McGill University Health Centre (RIMUHC), Montreal, Quebec H4A 3J1, Canada.
Marie Christine GuiotDepartment of Neuropathology, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada.
Zhi HeInstitute of Quantitative Biology, College of Life Sciences, Zhejiang University, Hangzhou, 310058 China.
Sebastian Wachsmann-HogiuDepartment of Bioengineering, McGill University, Montreal, Quebec H3A 0E9, Canada.ORCID 0000-0002-3761-3834
Ruhong ZhouInstitute of Quantitative Biology, College of Life Sciences, Zhejiang University, Hangzhou, 310058 China.ORCID 0000-0001-8624-5591
Kevin PetreccaDepartment of Neuropathology, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada.
Walter W ReisnerDepartment of Physics, McGill University, Montreal, Quebec H3A 2T8, Canada.ORCID 0000-0003-3223-615X
Janusz RakResearch Institute of the McGill University Health Centre (RIMUHC), Montreal, Quebec H4A 3J1, Canada.ORCID 0000-0002-2912-5566
Sara MahshidDepartment of Bioengineering, McGill University, Montreal, Quebec H3A 0E9, Canada.ORCID 0000-0003-4203-819X
McGill University · CAMcGill University Health Centre · CAMontreal Neurological Institute and Hospital · CAZhejiang University · CNYangzhou University · CN

Funding

CIHR
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are continually released from cancer cells into biofluids, carrying actionable molecular fingerprints of the underlying disease with considerable diagnostic and therapeutic potential. The scarcity, heterogeneity and intrinsic complexity of tumor EVs present a major technological challenge in real-time monitoring of complex cancers such as glioblastoma (GBM). Surface-enhanced Raman spectroscopy (SERS) outputs a label-free spectroscopic fingerprint for EV molecular profiling. However, it has not been exploited to detect known biomarkers at the single EV level. We developed a multiplex fluidic device with embedded arrayed nanocavity microchips (MoSERS microchip) that achieves 97% confinement of single EVs in a minute amount of fluid (<10 μL) and enables molecular profiling of single EVs with SERS. The nanocavity arrays combine two featuring characteristics: (1) An embedded MoS

Indexed as

Brain NeoplasmsExtracellular VesiclesGlioblastomaGliomaHumansMolybdenumSpectrum Analysis, RamanMolybdenumglioblastoma cancermonolayer MoS2plasmonic nanocavitysingle extracellular vesicle analysissurface-enhanced Raman spectroscopy

Identifiers

PMID37366177
PMCPMC10339787
OpenAlexW4382181453

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.