Evidence map›Paper›PMID 37365952›Full record

ArticleChemical communications (Cambridge, England)2023

Calcium-triggered DNA-mediated membrane fusion in synthetic cells.

Yen-Yu Hsu, Samuel J Chen, Julio Bernal-Chanchavac, Bineet Sharma, Hossein Moghimianavval, Nicholas Stephanopoulos, Allen P Liu

Open access · greenAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Membrane-Associated Biomolecules for Synthetic Cell Signalling.Chembiochem : a European journal of chemical biology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yen-Yu HsuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA. allenliu@umich.edu.
Samuel J ChenDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA. allenliu@umich.edu.ORCID http://orcid.org/0000-0001-8501-7175
Julio Bernal-ChanchavacSchool of Molecular Sciences, Arizona State University, Tempe, Arizona, USA.ORCID http://orcid.org/0000-0001-5093-4248
Bineet SharmaDepartment of Chemistry and Chemical Biology, Rutgers University, New Brunswick, New Jersey, USA.
Hossein MoghimianavvalDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA. allenliu@umich.edu.
Nicholas StephanopoulosSchool of Molecular Sciences, Arizona State University, Tempe, Arizona, USA.ORCID http://orcid.org/0000-0001-7859-410X
Allen P LiuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA. allenliu@umich.edu.ORCID http://orcid.org/0000-0002-0309-7018
University of Michigan · USArizona State University · USRutgers, The State University of New Jersey · US

Funding

Chemical synthesis of G protein-coupled receptors using sequential DNA-templated reactionsDP2GM132931 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI STEPHANOPOULOS, NICHOLAS · 2018 to 2018
$2.2M
Development of a mechanosensitive synthetic cell for mediating intercellular communication - Diversity SupplementR01EB030031 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIU, ALLEN PO-CHIH · 2020 to 2024
$1.3M
NIBIB NIH HHS R01 EB030031NIGMS NIH HHS DP2 GM132931
6 · The paper itself

Abstract

In cells, membrane fusion is mediated by SNARE proteins, whose activities are calcium-dependent. While several non-native membrane fusion mechanisms have been demonstrated, few can respond to external stimuli. Here, we develop a calcium-triggered DNA-mediated membrane fusion strategy where fusion is regulated using surface-bound PEG chains that are cleavable by the calcium-activated protease calpain-1.

Indexed as

Artificial CellsMembrane FusionCalciumSNARE ProteinsCalciumSNARE Proteins

Identifiers

PMID37365952
PMCPMC10527479
OpenAlexW4379647008

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.