Evidence map›Paper›PMID 37365888›Full record

ArticleeLife2023

Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity.

Guillem Torcal Garcia, Elisabeth Kowenz-Leutz, Tian V Tian, Antonis Klonizakis, Jonathan Lerner, Luisa De Andres-Aguayo, Valeriia Sapozhnikova, Clara Berenguer, Marcos Plana Carmona, Maria Vila Casadesus and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 5 countries.

Guillem Torcal Garcia *Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID 0000-0002-0843-7296
Elisabeth Kowenz-Leutz *Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Tian V Tian *Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID 0000-0002-9906-0980
Antonis Klonizakis *Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Jonathan LernerPerelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Luisa De Andres-AguayoCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Valeriia SapozhnikovaMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Clara BerenguerCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Marcos Plana CarmonaCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Maria Vila CasadesusCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Romain BulteauLaboratorie de Biologie et Modélisation de la Cellule, Université de Lyon, Lyon, France.ORCID 0000-0002-9128-8809
Mirko FrancesconiLaboratorie de Biologie et Modélisation de la Cellule, Université de Lyon, Lyon, France.
Sandra PeiroVall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
Philipp MertinsMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Kenneth ZaretPerelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Achim Leutz *Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Thomas Graf *Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID 0000-0003-2774-4117
Universitat Pompeu Fabra · ESMax Delbrück Center · DEHebron University · PSUniversité Claude Bernard Lyon 1 · FRUniversity of Pennsylvania · US

Funding

TRANS-ACTING FACTORS CAUSING CELL-SPECIFIC GENE CONTROLR01GM036477 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI ZARET, KENNETH · 1986 to 2023
$7.7M
NIGMS NIH HHS R01 GM036477
6 · The paper itself

Abstract

Here, we describe how the speed of C/EBPα-induced B cell to macrophage transdifferentiation (BMT) can be regulated, using both mouse and human models. The identification of a mutant of C/EBPα (C/EBPα

Indexed as

CCAAT-Enhancer-Binding Protein-alphaCell TransdifferentiationTrans-ActivatorsAnimalsCCAAT-Enhancer-Binding ProteinsCell DifferentiationChromatinHumansMethylationMiceProtein-Arginine N-MethyltransferasesProto-Oncogene ProteinsCCAAT-Enhancer-Binding Protein-alphaCCAAT-Enhancer-Binding ProteinsCEBPA protein, humanChromatincoactivator-associated arginine methyltransferase 1Protein-Arginine N-MethyltransferasesProto-Oncogene ProteinsTrans-Activatorsblood cell differentiationcell fatedevelopmental biologygene regulationlineage choicemousetranscription factortransdifferentiation

Identifiers

PMID37365888
PMCPMC10299824
OpenAlexW4382182329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.