Observational studyEuropean journal of heart failure2023
Prevalence, clinical characteristics and outcomes of heart failure patients with or without isolated or combined mitral and tricuspid regurgitation: An analysis from the ESC-HFA Heart Failure Long-Term Registry.
Observational study in European journal of heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07578129 (Improvement in Guideline-Directed Medical Therapy After Tricuspid Transcatheter Edge-to-Edge Repair in Participants With Reduced Left Ventricular Function), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improvement in Guideline-Directed Medical Therapy After Tricuspid Transcatheter Edge-to-Edge Repair in Participants With Reduced Left Ventricular Function
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- European Journal of Heart Failure expert consensus statement on transcatheter treatment of mitral regurgitation in heart failure.European journal of heart failure · 2025Guideline
- Multivalvular Involvement in Acute Heart Failure: Associations with One-Year Outcomes and the Right-Heart Phenotype.Medical sciences (Basel, Switzerland) · 2026Article
- Transcatheter Edge-to-Edge Repair for Tricuspid Regurgitation: Design and Rationale of the TEER-CHINA Trial.JACC. Asia · 2026Article
- Persistent Tricuspid Regurgitation Despite Mitral Transcatheter Edge-to-Edge Repair: Anticipate Early, Reassess Closely.Structural heart : the journal of the Heart Team · 2026Article
- Tricuspid regurgitation: standardized stepwise work-up from referral to expert heart valve centre.European heart journal · 2026Review
- Severe tricuspid regurgitation: aetiology, patient characteristics, and treatment: a multicentre, prospective registry.ESC heart failure · 2026Observational
- Combined Atrial Functional Mitral and Tricuspid Regurgitation in Atrial Fibrillation: Prevalence, Associated Factors, and Three-Dimensional Valve Remodeling.Journal of clinical medicine · 2026Article
- Explainable Lightweight AI for the Identification of Right-Sided Cardiac Dysfunction in a Saudi Arabian Diabetic Cohort.Journal of clinical medicine · 2026Article
- Navigating isolated tricuspid regurgitation: A practical guide to perioperative and periprocedural management.JTCVS open · 2026Article
- Focus on tricuspid valve-the European perspective.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Aetiology, prevalence, and prognosis.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Acute Heart Failure in Heart Failure with Preserved Ejection Fraction: A State-of-the-art Review from an International Expert Group.Cardiac failure review · 2026Review
- Valvular Heart Disease in Heart Failure with Preserved Ejection Fraction.Cardiac failure review · 2026Review
- Article
- Tricuspid Regurgitation Across the Spectrum of Heart Failure With Preserved Ejection Fraction.Journal of the American College of Cardiology · 2025Article
- A contemporary review on heart failure with improved ejection fraction.NPJ cardiovascular health · 2025Review
- Valvular Heart Disease and Its Association With Death in Advanced Heart Failure.Journal of the American Heart Association · 2025Article
- Evaluation and Management Principles for Chronic Right Heart Failure and Tricuspid Regurgitation.Current heart failure reports · 2025Review
- Optimizing Patient Registries for Regulatory Decision Making - Key Learnings From an HMA/EMA Multistakeholder Workshop.Clinical pharmacology and therapeutics · 2025Review
- Heart failure hospitalizations and clinical outcomes in patients undergoing tricuspid transcatheter edge-to-edge repair: Insights from EuroTR.European journal of heart failure · 2025Observational
Corrections and comments
- Erratum issued
Authors and funding
23 authors at 16 institutions in 13 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimMitral regurgitation (MR) and tricuspid regurgitation (TR) are common in patients with heart failure (HF). The aim of this study was to investigate prevalence, clinical characteristics and outcomes of patients with or without isolated or combined MR and TR across the entire HF spectrum. METHODS AND
resultsThe ESC-HFA EORP HF Long-Term Registry is a prospective, multicentre, observational study including patients with HF and 1-year follow-up data. Outpatients without aortic valve disease were included and stratified according to isolated or combined moderate/severe MR and TR. Among 11 298 patients, 7541 (67%) had no MR/TR, 1931 (17%) isolated MR, 616 (5.5%) isolated TR and 1210 (11%) combined MR/TR. Baseline characteristics were differently distributed across MR/TR categories. Compared to HF with reduced ejection fraction, HF with mildly reduced ejection fraction was associated with a lower risk of isolated MR (odds ratio [OR] 0.69; 95% confidence interval [CI] 0.60-0.80), and distinctly lower risk of combined MR/TR (OR 0.51; 95% CI 0.41-0.62). HF with preserved ejection fraction (HFpEF) was associated with a distinctly lower risk of isolated MR (OR 0.42; 95% CI 0.36-0.49), and combined MR/TR (OR 0.59; 95% 0.50-0.70), but a distinctly increased risk of isolated TR (OR 1.94; 95% CI 1.61-2.33). All-cause death, cardiovascular death, HF hospitalization and combined outcomes occurred more frequently in combined MR/TR, isolated TR and isolated MR versus no MR/TR. The highest incident rates were observed in isolated TR and combined MR/TR.
conclusionIn a large cohort of outpatients with HF, prevalence of isolated and combined MR and TR was relatively high. Isolated TR was driven by HFpEF and was burdened by an unexpectedly poor outcome.
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