Evidence map›Paper›PMID 37365785›Full record

ArticleCurrent computer-aided drug design2024

Virtual Screening of Flavonoids against

Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Won Sun Park, Jin-Hee Han, Yong-Soo Kwon, Hee-Jae Lee, Wanjoo Chun

Abstract read
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In one paragraph

Article in Current computer-aided drug design, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Muhammad YasirDepartment of Pharmacology, Kangwon National University School of Medicine, Chuncheon, 24341, Republic of Korea.
Jinyoung ParkDepartment of Pharmacology, Kangwon National University School of Medicine, Chuncheon, 24341, Republic of Korea.
Eun-Taek HanDepartment of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine, Chuncheon, 24341, Republic of Korea.
Won Sun ParkDepartment of Physiology, Kangwon National University School of Medicine, Chuncheon, 24341, Republic of Korea.
Jin-Hee HanDepartment of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine, Chuncheon, 24341, Republic of Korea.
Yong-Soo KwonCollege of Pharmacy, Kangwon National University School of Medicine, Chuncheon, 24341, Republic of Korea.
Hee-Jae LeeDepartment of Pharmacology, Kangwon National University School of Medicine, Chuncheon, 24341, Republic of Korea.
Wanjoo ChunDepartment of Pharmacology, Kangwon National University School of Medicine, Chuncheon, 24341, Republic of Korea.ORCID 0000-0003-1984-3545
Kangwon National University · KR

Funding

National Research Foundation of Korea (NRF) Grant No. 2021-R1A4A1031574
6 · The paper itself

Abstract

background

methodsIn this study,

resultsThe results showed the effectiveness of flavonoids, such as daidzein, genistein, kaempferol, and quercetin, in the DBP binding site. These flavonoids were found to bind in the active region of DBP. Furthermore, the stability of these four ligands was maintained throughout the 50 ns simulation, maintaining stable hydrogen bond formation with the active site residues of DBP.

conclusionThe present study suggests that flavonoids might be good candidates and novel agents against DBP-mediated RBC invasion of

Indexed as

FlavonoidsMolecular Docking SimulationMolecular Dynamics SimulationPlasmodium vivaxProtozoan ProteinsReceptors, Cell SurfaceAntigens, ProtozoanAntimalarialsBinding SitesHumansAntigens, ProtozoanAntimalarialsDuffy antigen binding protein, PlasmodiumFlavonoidsProtozoan ProteinsReceptors, Cell Surfaceanti-malarial drugFlavonoidshydrogen bond.molecular dockingmolecular dynamic simulationPlasmodium vivax

Identifiers

PMID37365785
OpenAlexW4382181695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.