ArticleArthritis care & research2023
Sex Differences in Pain and Quantitative Sensory Testing in Patients With Rheumatoid Arthritis.
Article in Arthritis care & research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Sex differences in rheumatoid arthritis: results of a cross-sectional study.Clinical rheumatology · 2026Article
- The Association Between Neuropathic Pain, Pain Intensity, and Inflammatory Activity in Rheumatoid Arthritis.Journal of clinical medicine · 2026Article
- Sex differences in pain-related biopsychosocial assessments in patients with axial spondyloarthritis.Arthritis research & therapy · 2026Article
- An Ecologically Valid Experimental Model for Repeated Evoked Pain Using a Wearable Device in Pain-Free Individuals: A Pilot Feasibility Study.Pain research & management · 2026Article
- Beyond Inflammation: Why Understanding the Brain Matters in Inflammatory Arthritis.Arthritis care & research · 2026Review
- Gender differences in psychological features and determinates of quality of life in axial spondyloarthritis and psoriatic arthritis: a cross-sectional study.BMC psychology · 2025Article
- C5a in the peripheral plasma of female fibromyalgia patients is elevated but not related to pain sensitivity as in healthy controls.Scientific reports · 2025Article
- Residual pain and fatigue are affected by disease perception in rheumatoid arthritis in sustained clinical and ultrasound remission.Clinical rheumatology · 2025Article
- Gender differences in brain activity underlying acupuncture sensations at LR3: a task-based fMRI study.Frontiers in human neuroscience · 2025Article
- [Assessment of residual symptoms in patients with axial spondyloarthritis with low disease activity and analysis of its related factors].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Sex-Specific Trends in the Prevalence of Osteoarthritis and Rheumatoid Arthritis From 2005 to 2021 in South Korea: Nationwide Cross-Sectional Study.JMIR public health and surveillance · 2024Article
- A Review of Difficult-to-Treat Rheumatoid Arthritis: Definition, Clinical Presentation, and Management.Current rheumatology reports · 2023Review
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveWomen with rheumatoid arthritis (RA) have higher pain and worse functional outcomes compared to men, even when treated with similar medications. The objective of this study was to identify sex differences in pain intensity, pain interference, and quantitative sensory tests (QST), which are independent of inflammation, in patients with RA.
methodsThis study is a post hoc analysis of participants in the Central Pain in Rheumatoid Arthritis cohort. Pain intensity was assessed using a 0-10 numeric rating scale. Pain interference was measured using a Patient-Reported Outcomes Measurement Information System computerized adaptive test. QST included pressure pain detection thresholds, temporal summation, and conditioned pain modulation. Women and men were compared using multiple linear regression, adjusted for age, education, race, research site, depression, obesity, RA disease duration, swollen joint count, and C-reactive protein.
resultsMean ± SD pain intensity was 5.32 ± 2.29 among women with RA, compared to 4.60 ± 2.23 among men with RA (adjusted difference 0.83 [95% confidence interval (95% CI) 0.14, 1.53]). Women with RA had lower pressure pain detection thresholds at the trapezius (adjusted difference -1.22 [95% CI -1.73, -0.72]), wrist (adjusted difference -0.57 [95% CI -1.07, -0.06]), and knee (adjusted difference -1.10 [95% CI -2.00, -0.21]). No statistically significant differences in pain interference, temporal summation, and conditioned pain modulation were observed.
conclusionWomen reported higher pain intensity and lower pressure pain detection thresholds (higher pain sensitivity) than men. However, pain interference, temporal summation, and conditioned pain modulation did not differ between men and women.
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