Evidence map›Paper›PMID 37365531›Full record

ArticleCellular & molecular biology letters2023

A novel tyrosine tRNA-derived fragment, tRF

Rui Zhao, Zhenming Yang, Bo Zhao, Wenjing Li, Yaohui Liu, Xiaoxue Chen, Jing Cao, Jiarui Zhang, Yan Guo, Licheng Xu and 4 more

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular biology letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Rui ZhaoDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Zhenming YangDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Bo ZhaoSchool of Forestry, Northeast Forestry University, Harbin, China.
Wenjing LiDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Yaohui LiuDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Xiaoxue ChenDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Jing CaoDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Jiarui ZhangDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Yan GuoDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Licheng XuDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Jinpeng WangDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Yanan SunDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Ming LiuDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. liumingorl@qq.com.
Linli TianDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. tianlinli78@163.com.ORCID http://orcid.org/0000-0002-8934-1607
Harbin Medical University · CNNortheast Forestry University · CN

Funding

China Postdoctoral Science Foundation 2020M681115National Natural Science Foundation of China 82072987National Natural Science Foundation of China 82103164National Natural Science Foundation of China 82173209National Natural Science Foundation of China 82273332Natural Science Foundation of Heilongjiang Province LH2019H014Youth Project of Heilongjiang Natural Science Foundation YQ2022H008
6 · The paper itself

Abstract

backgroundTransfer (t)RNA-derived small RNA (tsRNA), generated from precursor or mature tRNA, is a new type of small non-coding RNA (sncRNA) that has recently been shown to play a vital role in human cancers. However, its role in laryngeal squamous cell carcinoma (LSCC) remains unclear.

methodsWe elucidated the expression profiles of tsRNAs in four paired LSCC and non-neoplastic tissues by sequencing and verified the sequencing data by quantitative real-time PCR (qRT-PCR) of 60 paired samples. The tyrosine-tRNA derivative tRF

resultstRF

conclusionsOur data delineated the landscape of tsRNAs in LSCC and identified the oncogenic role of tRF

Indexed as

Head and Neck NeoplasmsLactic AcidCarcinogenesisGene Expression Regulation, NeoplasticHumansLactate Dehydrogenase 5RNARNA, TransferSquamous Cell Carcinoma of Head and NeckTyrosineLactate Dehydrogenase 5Lactic AcidRNARNA, TransferTyrosineLactateLDHALSCCtRFTyrtsRNAs

Identifiers

PMID37365531
PMCPMC10291753
OpenAlexW4382060150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.