Evidence map›Paper›PMID 37365524›Full record

ArticleBMC pulmonary medicine2023

Association of Ureaplasma infection pattern and azithromycin treatment effect with bronchopulmonary dysplasia in Ureaplasma positive infants: a cohort study.

Xueyu Chen, Xuemei Huang, Yanqing Lin, Bingchun Lin, Chunyu Yang, Zhifeng Huang, Chuanzhong Yang

Open access · goldAbstract read
In one paragraph

Article in BMC pulmonary medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Azithromycin for eradication ofArchives of disease in childhood. Fetal and neonatal edition · 2026
    Pooled it
  2. Article
  3. Review
  4. Article
  5. [Advances in clinical pharmacotherapy for neonatalZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. [Clinical characteristics ofZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xueyu ChenDepartment of Neonatology, The First School of Clinical Medicine, Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China.
Xuemei HuangDepartment of Neonatology, The First School of Clinical Medicine, Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China.
Yanqing LinDepartment of Neonatology, The First School of Clinical Medicine, Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China.
Bingchun LinDepartment of Neonatology, The First School of Clinical Medicine, Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China.
Chunyu YangDepartment of Radiology, The First School of Clinical Medicine, Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Guangzhou, China.
Zhifeng HuangDepartment of Neonatology, The First School of Clinical Medicine, Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China.
Chuanzhong YangDepartment of Neonatology, The First School of Clinical Medicine, Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China. yangczgd@smu.edu.cn.
Shenzhen Maternity and Child Healthcare Hospital · CNSouthern Medical University · CN

Funding

Liuzhou Science and Technology Bureau Self-funding Project 2020NBAB0115ZiShenzhen Fund for Guangdong Provincial Highlevel Clinical Key Specialties SZGSP009Shenzhen Science and Technology Innovation Committee JCYJ20190809170009528
6 · The paper itself

Abstract

backgroundIt is unclear whether Ureaplasma-associated pneumonia and azithromycin treatment affect the risk for bronchopulmonary dysplasia (BPD).

methodsA retrospective cohort study was performed in very low birth weight (VLBW) infants who tested positive for Ureaplasma within 72 h after birth in a tertiary unit. Chest X-ray (CXR) and laboratory test were performed before and after azithromycin treatment. Multivariate logistic regression analysis was used to identify the independent association between BPD and Ureaplasma-associated pneumonia, as well as BPD and effective azithromycin treatment.

resultsA total of 118 infants were included in the current study, of whom 36 developed BPD (defined as supplemental oxygen needed at postmenstrual age 36 weeks or discharge). The rate of BPD was significantly higher in infants with Ureaplasma-associated pneumonia (44.6%) compared to infants with Ureaplasma colonization (17.7%, P = 0.002). After adjusting for confounders, an effective azithromycin treatment was significantly associated with reduced risk of BPD [odd ratio (OR) 0.011; 95% confidence interval (CI): 0.000-0.250), whereas Ureaplasma-associated pneumonia was not significantly associated with BPD (OR 1.835; 95% CI: 0.548-6.147).

conclusionEffective Azithromycin treatment in Ureaplasma positive VLBW infants was associated with a reduced risk of BPD.

Indexed as

Bronchopulmonary DysplasiaUreaplasma InfectionsAzithromycinCohort StudiesHumansInfantInfant, NewbornInfant, PrematureRetrospective StudiesUreaplasmaAzithromycinChest X-rayInterstitial pneumoniaLung development

Identifiers

PMID37365524
PMCPMC10294412
OpenAlexW4382045361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.