Evidence map›Paper›PMID 37365503›Full record

ReviewBMC infectious diseases2023

Fatal septic shock due to disseminated coccidioidomycosis: a case series and review of the literature.

Piotr Wisniewski, Isaac McCool, John C Walsh, Chelsea Ausman, Jenifer Edmondson, Alexandra Perry, Evan C Ewers, Ryan C Maves

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. The impact of osteoarticular invasion byMedical mycology case reports · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Piotr WisniewskiOperational Infectious Diseases Directorate, Naval Health Research Center, San Diego, CA, USA.
Isaac McCoolUniformed Services University School of Medicine, Bethesda, MD, USA.
John C WalshDepartment of Pathology, Naval Medical Center San Diego, San Diego, CA, USA.
Chelsea AusmanUniformed Services University School of Medicine, Bethesda, MD, USA.
Jenifer EdmondsonUniformed Services University School of Medicine, Bethesda, MD, USA.
Alexandra PerryDepartment of Pulmonary and Critical Care Medicine, Naval Medical Center San Diego, San Diego, CA, USA.
Evan C EwersUniformed Services University School of Medicine, Bethesda, MD, USA.
Ryan C MavesUniformed Services University School of Medicine, Bethesda, MD, USA. rmaves@wakehealth.edu.
Uniformed Services University of the Health Sciences · USNaval Medical Center San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoccidioidomycosis is a fungal infection endemic to the southwestern United States and regions of Latin America. Disseminated disease occurs in < 1% of cases. Septic shock is even rarer, with high mortality despite therapy. We describe two cases of coccidioidal septic shock. Both patients were older men of Filipino ancestry presenting with respiratory failure and vasopressor-dependent shock. Antifungal drugs were initiated after failure to improve with empiric antibiotics; in both, Coccidioides was isolated from respiratory cultures. Despite aggressive care, both patients ultimately died of their infections. We provide a review of the published literature on this topic.

conclusionsMost of the 33 reported cases of coccidioidal septic shock occurred in men (88%) of non-white race and ethnicity (78%). The overall mortality rate was 76%. All survivors received amphotericin B as part of their treatment. Coccidioidomycosis-related septic shock is a rare disease with poor outcomes; delays in diagnosis and treatment are common. Improved diagnostic testing for coccidioidomycosis could enhance recognition of this disease in the future. Although data are limited, early treatment with amphotericin B in cases of coccidioidal septic shock may reduce mortality.

Indexed as

CoccidioidomycosisShock, SepticAgedAmphotericin BAntifungal AgentsCoccidioidesHumansMaleAmphotericin BAntifungal AgentsCoccidioidesCoccidioidomycosisSepsisSeptic shock

Identifiers

PMID37365503
PMCPMC10291775
OpenAlexW4382060290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.