Evidence map›Paper›PMID 37365314›Full record

ArticleNature plants2023

Next-generation ABACUS biosensors reveal cellular ABA dynamics driving root growth at low aerial humidity.

James Rowe, Mathieu Grangé-Guermente, Marino Exposito-Rodriguez, Rinukshi Wimalasekera, Martin O Lenz, Kartika N Shetty, Sean R Cutler, Alexander M Jones

Open access · hybridAbstract read
In one paragraph

Article in Nature plants, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
27.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 69 citations in OpenAlex.

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  18. A balance of metabolism and diffusion articulates a gibberellin hormone gradient in theProceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 5 countries.

James RoweSainsbury Laboratory, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-3523-4347
Mathieu Grangé-GuermenteSainsbury Laboratory, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5400-8038
Marino Exposito-RodriguezSainsbury Laboratory, University of Cambridge, Cambridge, UK.
Rinukshi WimalasekeraSainsbury Laboratory, University of Cambridge, Cambridge, UK.
Martin O LenzSainsbury Laboratory, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-1658-4368
Kartika N ShettySainsbury Laboratory, University of Cambridge, Cambridge, UK.
Sean R CutlerCenter for Plant Cell Biology and Institute for Integrative Genome Biology, and Department of Botany and Plant Sciences, University of California, Riverside, Riverside, CA, USA.
Alexander M JonesSainsbury Laboratory, University of Cambridge, Cambridge, UK. alexander.jones@slcu.cam.ac.uk.ORCID http://orcid.org/0000-0002-3662-2915
University of Cambridge · GBUniversity of California, Riverside · USUniversity of Sri Jayewardenepura · LK

Funding

RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/P018572/1
6 · The paper itself

Abstract

The plant hormone abscisic acid (ABA) accumulates under abiotic stress to recast water relations and development. To overcome a lack of high-resolution sensitive reporters, we developed ABACUS2s-next-generation Förster resonance energy transfer (FRET) biosensors for ABA with high affinity, signal-to-noise ratio and orthogonality-that reveal endogenous ABA patterns in Arabidopsis thaliana. We mapped stress-induced ABA dynamics in high resolution to reveal the cellular basis for local and systemic ABA functions. At reduced foliar humidity, root cells accumulated ABA in the elongation zone, the site of phloem-transported ABA unloading. Phloem ABA and root ABA signalling were both essential to maintain root growth at low humidity. ABA coordinates a root response to foliar stresses, enabling plants to maintain foraging of deeper soil for water uptake.

Indexed as

ArabidopsisArabidopsis ProteinsBiosensing TechniquesAbscisic AcidGene Expression Regulation, PlantHumidityPlant Growth RegulatorsPlant RootsWaterAbscisic AcidArabidopsis ProteinsPlant Growth RegulatorsWater

Identifiers

PMID37365314
PMCPMC10356609
OpenAlexW4382139362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.