ArticleNature neuroscience2023
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Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 63 citations in OpenAlex.
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- m6A deficiency induces dopaminergic neurodegeneration and progressive parkinsonism through a pathogenic loop with mitochondria.The Journal of clinical investigation · 2026Article
- m6A RNA methylation in neural plasticity, brain aging, and neurodegenerative vulnerability.Molecular brain · 2026Review
- The Future of Epigenetics: Emerging Technologies and Clinical Applications.ACS pharmacology & translational science · 2026Review
- Potential common pathogenesis of several neurodegenerative diseases.Neural regeneration research · 2026Article
- Multi-region mNature neuroscience · 2026Article
- Integrated multi-omics identification of m6A-SNP-related diagnostic biomarkers in amyotrophic lateral sclerosis.Frontiers in immunology · 2026Article
- Benchmarking pre-trained genomic language models for RNA sequence-related predictive applications.Nature communications · 2025Article
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- RNA methylation modifications in neurodegenerative diseases: Focus on their enzyme system.Journal of advanced research · 2025Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Yini Li *Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-2213-0650
Xiaoyang Dou *Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.
Jun Liu *Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.
Yu Xiao *Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.
Zhe ZhangDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lindsey HayesBrain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-4818-6054
Rong WuDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Xiujuan FuDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yingzhi YeDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bing YangLaboratory of Cellular and Developmental Biology, NIDDK Intramural Research Program, Bethesda, MD, USA.
Lyle W OstrowDepartment of Neurology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID 0000-0001-7158-5243
Chuan HeDepartment of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA. chuanhe@uchicago.edu.ORCID 0000-0003-4319-7424
Shuying SunDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. shuying.sun@jhmi.edu.ORCID 0000-0002-8449-7370
Johns Hopkins University · USHoward Hughes Medical Institute · USNational Institute of Diabetes and Digestive and Kidney Diseases · USTemple University · US
Funding
Transcriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4MSingle molecule study of C9ORF72 repeat RNA metabolisms in ALS/FTDRF1NS113820 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SUN, SHUYING, WU, BIN · 2020 to 2025
$6.2MRNA-based regulation of TDP-43 nuclear export in ALS/FTDR01NS123538 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HOKE, AHMET · 2021 to 2025
$2.4MThe role of m6A RNA methylation in C9ORF72-ALS/FTDRF1NS127925 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SUN, SHUYING · 2022 to 2024
$2.0MDirect Oxidative Nucleic Acids DemethylationR01ES030546 · NIEHS · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2019 to 2023
$1.9MMolecular mechanism of dipeptide repeat protein production from hexanucleotide repeats in C9ORF72-related ALS and FTDR01NS107347 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SUN, SHUYING · 2018 to 2022
$1.8MThe role of m6A RNA methylation in C9ORF72-ALS/FTDR01NS127925 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Shuying Sun · 2025 to 2026
$1.2MFG-nucleoporins and nuclear transport disruption in C9ORF72-ALS/FTDK08NS104273 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HAYES, LINDSEY RENAE · 2017 to 2021
$999kDysregulation of inhibitory synapse by poly-GR in C9ORF72-ALS/FTDR21AG072078 · NIA · JOHNS HOPKINS UNIVERSITY · PI SUN, SHUYING · 2021 to 2021
$450kHoward Hughes Medical InstituteNHGRI NIH HHS RM1 HG008935NIA NIH HHS R21 AG072078NIEHS NIH HHS R01 ES030546NINDS NIH HHS K08 NS104273NINDS NIH HHS R01 NS107347NINDS NIH HHS R01 NS123538NINDS NIH HHS R01 NS127925NINDS NIH HHS RF1 NS113820NINDS NIH HHS RF1 NS127925
Abstract
Repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we show that N
Indexed as
Amyotrophic Lateral SclerosisFrontotemporal DementiaAdenosineC9orf72 ProteinDipeptidesDNA Repeat ExpansionHumansRNARNA, MessengerAdenosineC9orf72 ProteinC9orf72 protein, humanDipeptidesN-methyladenosineRNARNA, Messenger
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.