Evidence map›Paper›PMID 37365294›Full record

ArticleLeukemia2023

NPM1 mutation reprograms leukemic transcription network via reshaping TAD topology.

Qian Lai, Karina Hamamoto, Huacheng Luo, Zachary Zaroogian, Caixian Zhou, Julia Lesperance, Jie Zha, Yi Qiu, Olga A Guryanova, Suming Huang and 1 more

Abstract readLetter
In one paragraph

Article in Leukemia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qian Lai *Department of Hematology, The First affiliated Hospital of Xiamen University, Xiamen University School of Medicine, Xiamen, 361003, China.ORCID 0000-0002-4282-7757
Karina Hamamoto *Division of Pediatric Hematology/Oncology, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Huacheng Luo *Division of Pediatric Hematology/Oncology, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Zachary ZaroogianDepartment of Pharmacology and therapeutics, University of Florida College of Medicine, Gainesville, FL, 32610, USA.
Caixian ZhouDivision of Pediatric Hematology/Oncology, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Julia LesperanceDivision of Pediatric Hematology/Oncology, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Jie ZhaDepartment of Hematology, The First affiliated Hospital of Xiamen University, Xiamen University School of Medicine, Xiamen, 361003, China.
Yi QiuDepartment of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.ORCID 0000-0002-3282-6072
Olga A GuryanovaDepartment of Pharmacology and therapeutics, University of Florida College of Medicine, Gainesville, FL, 32610, USA.ORCID 0000-0002-6514-8466
Suming HuangDivision of Pediatric Hematology/Oncology, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA. shuang4@pennstatehealth.psu.edu.ORCID 0000-0002-4788-2085
Bing XuDepartment of Hematology, The First affiliated Hospital of Xiamen University, Xiamen University School of Medicine, Xiamen, 361003, China. xubing@xmu.edu.cn.

Funding

Role of lncRNA mediated R-loops in CTCF boundary function and AML genome organizationR01CA260729 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Suming Huang, Mingjiang Xu · 2022 to 2026
$3.1M
Role of HOTTIP/beta-catenin-HOXA9/PRMT1 axis in hematopoietic and leukemic stem cellsR01CA264932 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI So Eric, Suming Huang · 2022 to 2026
$2.5M
The role of DNMT3A mutations in clonal heterogeneity and evolution of hematopoiesisR01DK121831 · NIDDK · UNIVERSITY OF FLORIDA · PI GURYANOVA, OLGA A · 2019 to 2023
$1.7M
Epigenetic regulation of hematopoiesisR01HL144712 · NHLBI · UNIVERSITY OF FLORIDA · PI QIU, YI · 2019 to 2022
$1.6M
NCI NIH HHS R01 CA260729NCI NIH HHS R01 CA264932NHLBI NIH HHS R01 HL144712NIDDK NIH HHS R01 DK121831
6 · The paper itself

Abstract

C-terminal mutation of Nucleophosmin 1 (NPM1

Indexed as

Gene Expression Regulation, LeukemicLeukemia, Myeloid, AcuteHematopoietic Stem CellsHumansMutationNuclear ProteinsNuclear Proteins

Identifiers

PMID37365294
PMCPMC10400418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.