Evidence map›Paper›PMID 37365285›Full record

ArticleBritish journal of cancer2023

Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses.

Niki Dimou, Andre E Kim, Orlagh Flanagan, Neil Murphy, Virginia Diez-Obrero, Anna Shcherbina, Elom K Aglago, Emmanouil Bouras, Peter T Campbell, Graham Casey and 78 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328677 (ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02328677 recruitingnot on this map

ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis

TypeobservationalSponsorUniversity of UtahRan2007 to 2030Enrolled5,000ConditionsColorectal Cancer
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

88 authors at 20 institutions in 16 countries.

Niki DimouNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France. DimouN@iarc.who.int.ORCID 0000-0003-1678-9328
Andre E KimDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Orlagh FlanaganNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.
Neil MurphyNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.ORCID 0000-0003-3347-8249
Virginia Diez-ObreroUnit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, 08908, Spain.
Anna ShcherbinaDepartment of Genetics, Stanford University, Stanford, CA, USA.
Elom K AglagoSchool of Public Health, Imperial College London, London, United Kingdom.ORCID 0000-0002-0442-3284
Emmanouil BourasDepartment of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.ORCID 0000-0003-1489-5506
Peter T CampbellDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Graham CaseyDepartment of Public Health Sciences, Center for Public Health Genomics, Charlottesville, VA, USA.
Steven GallingerLunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Stephen B GruberCenter for Precision Medicine, Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.
Mark A JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Yi LinPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Victor MorenoDepartment of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, 08908, Spain.ORCID 0000-0002-2818-5487
Edward Ruiz-NarvaezDepartment of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID 0000-0002-0339-5824
Mariana C SternDepartment of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Yu TianDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kostas K TsilidisSchool of Public Health, Imperial College London, London, United Kingdom.
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-9320-8684
Elizabeth L BarryDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
James W BaurleyBioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Stéphane BézieauNantes Université, CHU Nantes, Service de Génétique médicale, F-44000, Nantes, France.
Stephanie A BienPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
D Timothy BishopLeeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.ORCID 0000-0002-8752-8785
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-6129-1572
Arif BudiartoBioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.
Robert Carreras-TorresColorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 8908, Barcelona, Spain.
Tjeng Wawan CenggoroBioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7284-6767
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Xuechen ChenDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0003-2476-7110
David V ContiDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Christopher H DampierDepartment of Public Health Sciences, Center for Public Health Genomics, Charlottesville, VA, USA.
Matthew DevallDepartment of Family Medicine, University of Virginia, Charlottesville, VA, USA.
David A DrewClinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jane C FigueiredoDepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Graham G GilesCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Andrea GsurCenter for Cancer Research, Medical University of Vienna, Vienna, Austria.
Tabitha A HarrisonPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Akihisa HidakaPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-8307-3197
Jeroen R HuyghePublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0001-6027-9806
Kristina JordahlPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Eric KawaguchiDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Temitope O KekuCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.
Susanna C LarssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-0118-0341
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Juan Pablo LewingerDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Li LiDepartment of Family Medicine, University of Virginia, Charlottesville, VA, USA.
Bharuno MahesworoBioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.
John MorrisonDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Polly A NewcombPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0001-8786-0043
Christina C NewtonDepartment of Population Science, American Cancer Society, Atlanta, GA, USA.
Mireia Obon-SantacanaUnit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Avda Gran Via Barcelona 199-203, 08908L'Hospitalet de Llobregat, Barcelona, Spain.
Jennifer OseHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Rish K PaiDepartment of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ, USA.
Julie R PalmerSlone Epidemiology Center at Boston University, Boston, MA, USA.ORCID 0000-0002-6534-335X
Nikos PapadimitriouNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.
Bens PardameanBioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.
Anita R PeoplesHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Paul D P PharoahDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID 0000-0001-8494-732X
Elizabeth A PlatzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
John D PotterPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0001-5439-1500
Gad RennertDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.
Peter C ScacheriDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
Robert E SchoenDepartment of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Yu-Ru SuBiostatistics Division, Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Catherine M TangenSWOG Statistical Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Stephen N ThibodeauDivision of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Duncan C ThomasDepartment of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Cornelia M UlrichHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Caroline Y UmDepartment of Population Science, American Cancer Society, Atlanta, GA, USA.ORCID 0000-0001-5449-6230
Franzel J B van DuijnhovenDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
Kala VisvanathanDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.ORCID 0000-0002-0582-8005
Pavel VodickaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Ludmila VodickovaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Emily WhitePublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7387-6845
Michael O WoodsMemorial University of Newfoundland, Discipline of Genetics, St. John's, NL, Canada.
Conghui QuPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Anshul Kundaje *Department of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0003-3084-2287
Li Hsu *Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
W James Gauderman *Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Marc J Gunter *Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.
Ulrike Peters *Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Fred Hutch Cancer Center · USUniversity of Southern California · USUniversity of Washington · USBinus University · IDCentre international de recherche sur le cancer · FRGerman Cancer Research Center · DEInstitut d'Investigació Biomédica de Bellvitge · ESUniversity of Utah · USAmerican Cancer Society · USCharles University · CZDartmouth College · USKarolinska Institutet · SENational Institutes of Health · USOffice of Public Health Genomics · USStanford University · USThe University of Melbourne · AUUniversity of Ioannina · GRAlbert Einstein College of Medicine · USBellvitge University Hospital · ESBoston University · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
SWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
SWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI RIMM, ERIC B · 1991 to 2009
$41.8M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Paul Marjoram · 2016 to 2026
$25.5M
JH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2M
Cancer Research UK 14136Cancer Research UK 29019Cancer Research UK C18281/A29019Cancer Research UK C588/A19167Medical Research Council 1000143Medical Research Council MR/M012190/1NCATS NIH HHS KL2 TR000421NCI NIH HHS K05 CA152715NCI NIH HHS K05 CA154337NCI NIH HHS P01 CA033619NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS P01 CA196569NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA059045NCI NIH HHS R01 CA066635NCI NIH HHS R01 CA072520NCI NIH HHS R01 CA076366NCI NIH HHS R01 CA081488NCI NIH HHS R01 CA097325NCI NIH HHS R01 CA136726NCI NIH HHS R01 CA137178NCI NIH HHS R01 CA143237NCI NIH HHS R01 CA151993NCI NIH HHS R01 CA155101NCI NIH HHS R01 CA197350NCI NIH HHS R01 CA201407NCI NIH HHS R01 CA206279NCI NIH HHS R01 CA242218NCI NIH HHS R03 CA153323NCI NIH HHS R35 CA197735NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA063464NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA086308NCI NIH HHS U01 CA122839NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA164930NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA167552NCI NIH HHS U01 CA182883NCI NIH HHS U01 CA206110NCI NIH HHS U10 CA037429NCI NIH HHS U19 CA148107NCI NIH HHS U24 CA074794NCI NIH HHS UG1 CA189974NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA182883NCI NIH HHS UM1 CA186107NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NHLBI NIH HHS HHSN268201200008INHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNIA NIH HHS U01 AG018033NIDDK NIH HHS P30 DK034987NIDDK NIH HHS P30 DK056350NIEHS NIH HHS T32 ES013678NIH HHS S10 OD028685World Health Organization 001
6 · The paper itself

Abstract

backgroundDiabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by genetic variants. To address these questions, we undertook a genome-wide gene-environment interaction analysis.

methodsWe used data from 3 genetic consortia (CCFR, CORECT, GECCO; 31,318 colorectal cancer cases/41,499 controls) and undertook genome-wide gene-environment interaction analyses with colorectal cancer risk, including interaction tests of genetics(G)xdiabetes (1-degree of freedom; d.f.) and joint testing of Gxdiabetes, G-colorectal cancer association (2-d.f. joint test) and G-diabetes correlation (3-d.f. joint test).

resultsBased on the joint tests, we found that the association of diabetes with colorectal cancer risk is modified by loci on chromosomes 8q24.11 (rs3802177, SLC30A8 - OR DISCUSSION: These results suggest that variation in genes related to insulin signaling (SLC30A8) and immune function (LRCH1) may modify the association of diabetes with colorectal cancer risk and provide novel insights into the biology underlying the diabetes and colorectal cancer relationship.

Indexed as

Colorectal NeoplasmsDiabetes MellitusGene-Environment InteractionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMicrofilament ProteinsPolymorphism, Single NucleotideRisk FactorsLRCH1 protein, humanMicrofilament Proteins

Identifiers

PMID37365285
PMCPMC10403521
OpenAlexW4382046876

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.