Evidence map›Paper›PMID 37365239›Full record

ArticleMolecular psychiatry2023

Chemogenetic manipulation of CX3CR1

Shunyi Zhao, Jiaying Zheng, Lingxiao Wang, Anthony D Umpierre, Sebastian Parusel, Manling Xie, Aastha Dheer, Katayoun Ayasoufi, Aaron J Johnson, Jason R Richardson and 1 more

Open access · greenAbstract read
In one paragraph

Article in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Microglia contribute to bipolar depression through Serinc2-dependent phospholipid synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Gene therapy for chronic pain management.Cell reports. Medicine · 2024
    Review
  6. CCR2Cell reports · 2024
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Shunyi Zhao *Department of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-7265-0801
Jiaying Zheng *Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Lingxiao WangDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-7525-7431
Anthony D UmpierreDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Sebastian ParuselDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Manling XieDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Aastha DheerDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-3289-1402
Katayoun AyasoufiDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.
Aaron J JohnsonDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Jason R RichardsonDepartment of Environmental Health Science, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL, USA.
Long-Jun WuDepartment of Neurology, Mayo Clinic, Rochester, MN, USA. wu.longjun@mayo.edu.ORCID 0000-0001-8019-3380
Mayo Clinic in Arizona · USMayo Clinic · USFlorida International University · US

Funding

Microglial Hv1 Proton Channel as a Mediator of Environmentally-Induced Neuroinflammation and NeurodegenerationR01ES033892 · NIEHS · UNIVERSITY OF GEORGIA · PI Jason R Richardson, Long-Jun Wu · 2022 to 2026
$3.4M
How microglia sense and regulate neuronal activity in the adult brainR35NS132326 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Long-Jun Wu · 2023 to 2026
$3.2M
The role of microglia in neuromyelitis opticaR01NS110949 · NINDS · MAYO CLINIC ROCHESTER · PI LENNON, VANDA A, WU, LONG-JUN · 2020 to 2024
$2.0M
Microglial regulation of neuronal activity in TDP-43 neurodegenerationRF1AG082314 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI WU, LONG-JUN · 2023 to 2023
$1.9M
Microglial regulation of neuronal activity in TDP-43 neurodegenerationR01AG082314 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Long-Jun Wu · 2026 to 2026
$712k
Microglial P2Y6 receptor calcium signaling as a core regulator of epileptogenesisK99NS126417 · NINDS · MAYO CLINIC ROCHESTER · PI UMPIERRE, ANTHONY DAVID · 2022 to 2023
$236k
NIA NIH HHS R01 AG082314NIA NIH HHS RF1 AG082314NIEHS NIH HHS R01 ES033892NINDS NIH HHS K99 NS126417NINDS NIH HHS R01 NS110949NINDS NIH HHS R35 NS132326
6 · The paper itself

Abstract

Chemogenetic approaches using Designer Receptors Exclusively Activated by Designer Drugs (DREADD, a family of engineered GPCRs) were recently employed in microglia. Here, we used Cx3cr1

Indexed as

MicrogliaNeuronsAnimalsMacrophagesMice

Identifiers

PMID37365239
PMCPMC10906107
OpenAlexW4382024815

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.