Evidence map›Paper›PMID 37365017›Full record

ReviewWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Cutaneous changes in diabetic patients: Primed for aberrant healing?

Vivien Y Chen, Lindsey G Siegfried, Marjana Tomic-Canic, Rivka C Stone, Irena Pastar

Open access · hybridAbstract readReview
In one paragraph

Review in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Current drug discovery technologies · 2025
    Article
  8. Review
  9. Review
  10. Evaluation of c-Myc and Phosphorylated Glucocorticoid Receptor (p-GR) for Predicting Diabetic Foot Ulcer Healing-A Diabetic Foot Consortium Study.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Vivien Y ChenWound Healing and Regenerative Medicine Research Program, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
Lindsey G SiegfriedWound Healing and Regenerative Medicine Research Program, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.ORCID 0000-0002-6561-4113
Marjana Tomic-CanicWound Healing and Regenerative Medicine Research Program, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.ORCID 0000-0002-9341-0193
Rivka C StoneWound Healing and Regenerative Medicine Research Program, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
Irena PastarWound Healing and Regenerative Medicine Research Program, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.ORCID 0000-0003-0197-6198
University of Miami · US

Funding

Prevention of intracellular infection in diabetic wounds by commensal Staphylococcus epidermidisR01DK136241 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Irena Pastar, NATASA STRBO · 2023 to 2026
$2.8M
University of Miami Clinical Research Unit of the Diabetic Foot ConsortiumU01DK119085 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI KIRSNER, ROBERT SCOTT, LEV-TOV, HADAR · 2018 to 2022
$1.8M
Circulating urinary microRNAs as systemic biomarkers of healing outcomes in diabetic foot ulcersR61DK131897 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI STONE, RIVKA C., TOMIC-CANIC, MARJANA · 2022 to 2023
$821k
NIDDK NIH HHS 1R01DK136241NIDDK NIH HHS 1R61DK131897NIDDK NIH HHS R01 DK136241NIDDK NIH HHS R61 DK131897NIDDK NIH HHS U01 DK119085
6 · The paper itself

Abstract

Cutaneous manifestations affect most patients with diabetes mellitus, clinically presenting with numerous dermatologic diseases from xerosis to diabetic foot ulcers (DFUs). Skin conditions not only impose a significantly impaired quality of life on individuals with diabetes but also predispose patients to further complications. Knowledge of cutaneous biology and the wound healing process under diabetic conditions is largely limited to animal models, and studies focusing on biology of the human condition of DFUs remain limited. In this review, we discuss the critical molecular, cellular, and structural changes to the skin in the hyperglycaemic and insulin-resistant environment of diabetes with a focus specifically on human-derived data. Elucidating the breadth of the cutaneous manifestations coupled with effective diabetes management is important for improving patient quality of life and averting future complications including wound healing disorders.

Indexed as

Diabetes MellitusDiabetic FootAnimalsHumansQuality of LifeSkinWound Healingdiabetesdiabetic foot ulcerglycationhyperglycaemiainflammationneuropathyskinwound healing

Identifiers

PMID37365017
PMCPMC10966665
OpenAlexW4382047353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.